动态血糖监测指导下个体化营养和胰岛素泵治疗2型糖尿病后空腹c肽(FC-P)、空腹胰岛素(FIns)和糖化血红蛋白(HbA1c)的血清值

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Qing Zhou, Li Zou, Yan Gao, Hua Ma, Yaping Guo, Guohong Zhu
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引用次数: 0

摘要

背景:2型糖尿病(T2DM)是一种以糖代谢受损为特征的慢性代谢性疾病,需要对血糖(BG)、血压和血脂进行综合管理。本研究旨在评价在持续血糖监测(CGM)和质量循环控制(QCC)护理模式指导下,个体化营养和胰岛素泵治疗对T2DM患者各种生物标志物的临床效果,包括空腹c肽(FC-P)、空腹血糖(FPG)、餐后2小时血糖(2hPG)、空腹胰岛素(FIns)和糖化血红蛋白(HbA1c)。方法:选取2023年1月至2024年1月在我院治疗的80例T2DM患者作为研究对象。患者被分配到实验组(EG),接受个性化营养和胰岛素泵治疗,由CGM和QCC护理模式支持,或常规组(RG),接受标准护理。比较两组在血糖控制、胰岛素使用、CGM系统性能(包括停机和异常率)和患者满意度方面的差异。结果:与对照组相比,EG组的FC-P、FPG、2hPG、FIns和HbA1c水平均有显著改善(结论:QCC护理模式与CGM指导下的个体化营养和胰岛素泵治疗相结合,可显著增强血糖控制,优化胰岛素治疗,改善患者预后,包括饮食习惯、生活质量和降低低血糖事件。该模型有望成为管理2型糖尿病的有效策略,值得在临床实践中进一步采用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Serum value of fasting C-peptide (FC-P), fasting insulin (FIns), and glycated hemoglobin (HbA1c) after dynamic blood glucose monitoring-guided personalised nutrition and insulin pump therapy for type II diabetes mellitus.

Serum value of fasting C-peptide (FC-P), fasting insulin (FIns), and glycated hemoglobin (HbA1c) after dynamic blood glucose monitoring-guided personalised nutrition and insulin pump therapy for type II diabetes mellitus.

Serum value of fasting C-peptide (FC-P), fasting insulin (FIns), and glycated hemoglobin (HbA1c) after dynamic blood glucose monitoring-guided personalised nutrition and insulin pump therapy for type II diabetes mellitus.

Serum value of fasting C-peptide (FC-P), fasting insulin (FIns), and glycated hemoglobin (HbA1c) after dynamic blood glucose monitoring-guided personalised nutrition and insulin pump therapy for type II diabetes mellitus.

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterised by impaired glucose metabolism, which necessitates comprehensive management of blood glucose (BG), blood pressure, and lipid profiles. This study aimed to evaluate the clinical effects of individualised nutrition and insulin pump therapy, guided by continuous glucose monitoring (CGM) and the Quality Circle Control (QCC) nursing model, on various biomarkers in T2DM patients, including fasting C-peptide (FC-P), fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG), fasting insulin (FIns), and glycated haemoglobin (HbA1c).

Methods: Eighty T2DM patients treated at our hospital were enrolled in the study between January 2023 and January 2024. Patients were assigned to either the experimental group (EG), which received individualised nutrition and insulin pump therapy supported by CGM and the QCC nursing model, or the regular group (RG), which received standard care. Differences in BG control, insulin usage, CGM system performance (including downtime and anomaly rates), and patient satisfaction were compared between the two groups.

Results: The EG demonstrated significant improvements in FC-P, FPG, 2hPG, FIns, and HbA1c levels compared to the RG (P<0.05). Specifically, the EG showed more rapid achievement of BG targets, reduced glucose variability, lower insulin usage, and decreased CGM system anomalies.

Conclusions: The QCC nursing model, when integrated with individualised nutrition and insulin pump therapy guided by CGM, significantly enhances blood glucose control, optimises insulin therapy, and improves patient outcomes, including dietary habits, quality of life, and reduction in hypoglycemic events. This model shows promise as an effective strategy for managing T2DM and warrants further adoption in clinical practice.

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来源期刊
Journal of Medical Biochemistry
Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.00
自引率
12.00%
发文量
60
审稿时长
>12 weeks
期刊介绍: The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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