重组III型胶原蛋白在组织工程中的应用。

IF 2.9 4区医学 Q3 ENGINEERING, BIOMEDICAL

BioMedical Engineering OnLine Pub Date : 2025-10-06 DOI:10.1186/s12938-025-01447-9

Yuchen Shan, Ting Wang, Haiyan Lin

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引用次数: 0

摘要

重组人ⅲ型胶原（rhCol III）具有良好的生物相容性和生物活性，是一种很有前途的组织工程生物材料。本文综述了rhCol III的结构、发展及其在骨和软组织工程中的应用。基因工程的进步使rhCol III的生产具有可定制的特性。它在促进组织修复和再生中起着关键作用，在伤口愈合、皮肤修复和抗炎反应中具有重要的潜力。然而，在优化其特定应用的机械性能方面仍然存在挑战。未来的研究应侧重于提高生产效率和临床翻译，同时解决潜在的宿主反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Applications of recombinant type III collagen in tissue engineering.

Recombinant human type III collagen (rhCol III) is a promising biomaterial for tissue engineering due to its excellent biocompatibility and bioactivity. This review summarizes the structure, development, and applications of rhCol III in bone and soft tissue engineering. Advances in genetic engineering have enabled the production of rhCol III with customizable properties. It plays a key role in promoting tissue repair and regeneration, with significant potential in wound healing, skin repair, and anti-inflammatory responses. However, challenges remain in optimizing its mechanical properties for specific applications. Future research should focus on improving production efficiency and clinical translation while addressing potential host responses.

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来源期刊

BioMedical Engineering OnLine 工程技术-工程：生物医学

CiteScore

6.70

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： BioMedical Engineering OnLine is an open access, peer-reviewed journal that is dedicated to publishing research in all areas of biomedical engineering. BioMedical Engineering OnLine is aimed at readers and authors throughout the world, with an interest in using tools of the physical and data sciences and techniques in engineering to understand and solve problems in the biological and medical sciences. Topical areas include, but are not limited to: Bioinformatics- Bioinstrumentation- Biomechanics- Biomedical Devices & Instrumentation- Biomedical Signal Processing- Healthcare Information Systems- Human Dynamics- Neural Engineering- Rehabilitation Engineering- Biomaterials- Biomedical Imaging & Image Processing- BioMEMS and On-Chip Devices- Bio-Micro/Nano Technologies- Biomolecular Engineering- Biosensors- Cardiovascular Systems Engineering- Cellular Engineering- Clinical Engineering- Computational Biology- Drug Delivery Technologies- Modeling Methodologies- Nanomaterials and Nanotechnology in Biomedicine- Respiratory Systems Engineering- Robotics in Medicine- Systems and Synthetic Biology- Systems Biology- Telemedicine/Smartphone Applications in Medicine- Therapeutic Systems, Devices and Technologies- Tissue Engineering