Phenolic Derivatives in Hypochlorite-Scavenging Model: Theoretical and Practical Approach

The antioxidant activity of lactamomethyl derivatives of alkylphenols and polyhydroxyphenols was studied based on their ability to inhibit the oxidation of taurine by the hypochlorite anion. Quantitative measurements were carried out spectrophotometrically. For twelve compounds, IC₅₀ values of oxidation inhibition were determined, and derivatives of polyhydroxyphenols were shown to be several orders of magnitude more active than alkylphenol ones. Most of the compounds proved to be more effective than the known antioxidants BHT, n-propyl gallate, and quercetin. To identify a correlation between the structure of the compounds and their activity, quantum chemical methods were used to determine their key parameters, and it was found that the antioxidant activity of the compounds in the hypochlorite anion absorption model depends on the stability of the cationic intermediates formed.