I. S. Usataia, V. O. Graur, P. N. Bourosh, E. I. Melnic, G. G. Balan, C. S. Lozan-Tirsu, O. S. Garbuz, A. P. Gulea
{"title":"与2-甲酰基和2-乙酰吡啶的4，s -二烯基异硫代氨基脲基金属配位化合物的合成、结构和生物活性","authors":"I. S. Usataia, V. O. Graur, P. N. Bourosh, E. I. Melnic, G. G. Balan, C. S. Lozan-Tirsu, O. S. Garbuz, A. P. Gulea","doi":"10.1134/S1070363225604521","DOIUrl":null,"url":null,"abstract":"<p>Eight novel coordination compounds of nickel(II), cobalt(III), and iron(III) with 4,<i>S</i>-diallylisothiosemicarbazones of 2-formylpyridine (HL<sup>1</sup>) and 2-acetylpyridine (HL<sup>2</sup>) were synthesized: [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Ni(HL<sup>1</sup>)<sub>2</sub>](I)<sub>2</sub>, [Co(L<sup>1</sup>)<sub>2</sub>]I, [Co(L<sup>2</sup>)<sub>2</sub>]I, [Fe(L<sup>1</sup>)<sub>2</sub>]NO<sub>3</sub>, [Fe(L<sup>1</sup>)<sub>2</sub>]Br, [Fe(L<sup>2</sup>)<sub>2</sub>]NO<sub>3</sub>. The isothiosemicarbazone ligands were characterized by NMR and IR spectroscopy. All coordination compounds were characterized by elemental analysis, IR spectroscopy, and molar conductivity measurements of their 1 mM solutions in methanol. Furthermore, the crystal structures of the complexes [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Ni(HL<sup>1</sup>)<sub>2</sub>](I)<sub>2</sub> were determined by single-crystal X-ray diffraction (SC-XRD). The investigated complexes exhibited antibacterial, antifungal, and antiradical activity against ABTS<sup>•+</sup> cation radicals. The complexes [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Co(L<sup>1</sup>)<sub>2</sub>]I, [Fe(L<sup>1</sup>)<sub>2</sub>]NO<sub>3</sub> demonstrated superior antiradical activity compared to Trolox, a standard antioxidant used in medical practice.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 9","pages":"2390 - 2401"},"PeriodicalIF":0.8000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, Structure, and Biological Activity of New Coordination Compounds of Selected 3d-Metals with 4,S-Diallylisothiosemicarbazones of 2-Formyl- and 2-Acetylpyridine\",\"authors\":\"I. S. Usataia, V. O. Graur, P. N. Bourosh, E. I. Melnic, G. G. Balan, C. S. Lozan-Tirsu, O. S. Garbuz, A. P. Gulea\",\"doi\":\"10.1134/S1070363225604521\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Eight novel coordination compounds of nickel(II), cobalt(III), and iron(III) with 4,<i>S</i>-diallylisothiosemicarbazones of 2-formylpyridine (HL<sup>1</sup>) and 2-acetylpyridine (HL<sup>2</sup>) were synthesized: [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Ni(HL<sup>1</sup>)<sub>2</sub>](I)<sub>2</sub>, [Co(L<sup>1</sup>)<sub>2</sub>]I, [Co(L<sup>2</sup>)<sub>2</sub>]I, [Fe(L<sup>1</sup>)<sub>2</sub>]NO<sub>3</sub>, [Fe(L<sup>1</sup>)<sub>2</sub>]Br, [Fe(L<sup>2</sup>)<sub>2</sub>]NO<sub>3</sub>. The isothiosemicarbazone ligands were characterized by NMR and IR spectroscopy. All coordination compounds were characterized by elemental analysis, IR spectroscopy, and molar conductivity measurements of their 1 mM solutions in methanol. Furthermore, the crystal structures of the complexes [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Ni(HL<sup>1</sup>)<sub>2</sub>](I)<sub>2</sub> were determined by single-crystal X-ray diffraction (SC-XRD). The investigated complexes exhibited antibacterial, antifungal, and antiradical activity against ABTS<sup>•+</sup> cation radicals. The complexes [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Co(L<sup>1</sup>)<sub>2</sub>]I, [Fe(L<sup>1</sup>)<sub>2</sub>]NO<sub>3</sub> demonstrated superior antiradical activity compared to Trolox, a standard antioxidant used in medical practice.</p>\",\"PeriodicalId\":761,\"journal\":{\"name\":\"Russian Journal of General Chemistry\",\"volume\":\"95 9\",\"pages\":\"2390 - 2401\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of General Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070363225604521\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363225604521","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis, Structure, and Biological Activity of New Coordination Compounds of Selected 3d-Metals with 4,S-Diallylisothiosemicarbazones of 2-Formyl- and 2-Acetylpyridine
Eight novel coordination compounds of nickel(II), cobalt(III), and iron(III) with 4,S-diallylisothiosemicarbazones of 2-formylpyridine (HL1) and 2-acetylpyridine (HL2) were synthesized: [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Ni(HL1)2](I)2, [Co(L1)2]I, [Co(L2)2]I, [Fe(L1)2]NO3, [Fe(L1)2]Br, [Fe(L2)2]NO3. The isothiosemicarbazone ligands were characterized by NMR and IR spectroscopy. All coordination compounds were characterized by elemental analysis, IR spectroscopy, and molar conductivity measurements of their 1 mM solutions in methanol. Furthermore, the crystal structures of the complexes [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Ni(HL1)2](I)2 were determined by single-crystal X-ray diffraction (SC-XRD). The investigated complexes exhibited antibacterial, antifungal, and antiradical activity against ABTS•+ cation radicals. The complexes [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Co(L1)2]I, [Fe(L1)2]NO3 demonstrated superior antiradical activity compared to Trolox, a standard antioxidant used in medical practice.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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