短花甲酰胺X、Y、Z的全合成

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-07 DOI:10.1039/d5cc05319f

Monosij Nandy, Apurba Das, Debgopal Jana, Satadru Dutta, Alakesh Bisai

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引用次数: 0

摘要

短甲酰胺X(1)和Y(2)是双环[2.2.2]重氮辛烷生物碱家族中相对较新的成员，其生物合成起源尚未确定。我们报道了(+)-brevianamide Y (2)， Z（16）和（+/-）brevianamide X(1)通过羟基脯氨酸引导级联的不对称全合成。氧化时间控制分化，提供简洁的路线，并强调羟基脯氨酸作为一个特殊的支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Total Synthesis of Brevianamides X, Y and Z

Brevianamides X (1) and Y (2) are relatively new members of the bicyclo[2.2.2]diazaoctane alkaloid family, whose biosynthetic origins remain unresolved. We report the asymmetric total synthesis of (+)-brevianamides Y (2), Z (16) and (+/-) brevianamide X (1) through a hydroxyproline-guided cascade. Oxidation timing governs divergence, affording concise routes and underscoring hydroxyproline as a privileged scaffold.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.