二苯甲酮介导的光催化[4 + 2]环化反应合成四氢喹啉

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-10-07 DOI:10.1002/adsc.70063

Jinke Chen, Keying Chen, Juan Zhang, Jinping Tan, Jihong Gu, Kaipeng Huang, Jiansong Fang, Wentao Wei

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引用次数: 0

摘要

本文报道了二苯甲酮作为光敏剂促进叔苯胺和烯烃的分子间自由基串联反应，促进单电子转移、氢原子转移和α -氨基烷基自由基的形成。该反应在温和的条件下进行，表现出广泛的底物耐受性和高的非对映选择性，并证实了反应体系中产生氢气，为四氢喹啉衍生物的合成提供了一种方便高效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photocatalytic [4 + 2] Annulation Reaction of Amine and Olefin Mediated by Benzophenone for Tetrahydroquinoline Synthesis

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Photocatalytic [4 + 2] Annulation Reaction of Amine and Olefin Mediated by Benzophenone for Tetrahydroquinoline Synthesis

Herein, the intermolecular radical tandem reaction of tertiary aniline and olefin promoted by benzophenone, which acts as a photosensitizer to accelerate single‐electron transfer, hydrogen atom transfer, and α‐aminoalkyl radical formation is reported. The reaction proceeds under mild conditions, exhibits a broad substrate tolerance and high diastereoselectivity, as well as confirms that hydrogen gas is produced in the reaction system, providing a convenient and efficient method for the synthesis of tetrahydroquinoline derivatives.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.