E3泛素连接酶RNF114在健康和疾病中的新作用。

IF 3.1 3区生物学 Q3 CELL BIOLOGY

Human Cell Pub Date : 2025-10-05 DOI:10.1007/s13577-025-01305-9

Qian Wang, Shihan Cao, Zhenzhen Sun, Zhanjun Jia, Shiwei Yang

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引用次数: 0

摘要

泛素化通过影响底物的亚细胞定位、功能和降解，在各种生物过程和疾病中发挥重要作用。多种泛素相关酶共同介导泛素与底物的结合。在过去的几十年里，许多E3泛素连接酶，包括环指蛋白114 (RNF114)，已经得到了很好的研究。研究表明，RNF114参与多种生物过程，包括胚胎发育、细胞周期、基因组稳定性、免疫反应和破骨细胞发生。此外，RNF114与多种疾病有关，如病毒感染、牛皮癣、肝纤维化和癌症。本文综述了RNF114的最新研究进展，并为今后的研究提供了可能的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging role of the E3 ubiquitin ligase RNF114 in health and disease.

Ubiquitination plays important roles in various biological processes and diseases by affecting the subcellular localization, function, and degradation of substrates. Multiple ubiquitin-associated enzymes jointly mediate the binding of ubiquitin to substrates. Over the past few decades, numerous E3 ubiquitin ligases, including RING finger protein 114 (RNF114), have been well studied. Research has revealed the involvement of RNF114 in various biological processes, including embryonic development, the cell cycle, genome stability, the immune response, and osteoclastogenesis. Additionally, RNF114 is implicated in multiple diseases, such as viral infections, psoriasis, liver fibrosis, and cancer. This review recapitulates the most recent advances regarding RNF114 and provides possible directions for future research.

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来源期刊

Human Cell CELL BIOLOGY-

CiteScore

5.90

自引率

2.30%

发文量

176

审稿时长

4.5 months

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.