γδ T细胞调节体液免疫：一种潜在的疫苗佐剂策略。

3区医学 Q2 Medicine

Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-05-23 DOI:10.1016/bs.ai.2025.05.001

Kirsty Emery, Matthias Eberl

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引用次数: 0

摘要

疫苗接种可以说是减少传染病影响的最有效干预措施。然而，许多疫苗只能提供部分或短暂的保护，这促使我们基于对CD4+ T滤泡辅助细胞（Tfh）在体液免疫中的关键作用以及它们如何与B细胞相互作用的日益了解，需要更有效的解决方案。本文综述了γδ T细胞如何通过与Tfh和B细胞的串扰增强抗体反应，这可能导致新的佐剂策略，以提高疫苗接种效果，实现持久的保护性免疫，并预防全球重要的重大传染病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination.

Vaccination is arguably the most effective intervention in reducing the impact of infectious diseases. However, many vaccines provide only partial or transient protection, prompting the need for more effective solutions based on our growing understanding of the pivotal role of CD4⁺ T follicular helper (Tfh) cells in humoral immunity and how they interact with B cells. Here we review how γδ T cells can boost antibody responses via crosstalk with both Tfh and B cells, which could lead to new adjuvant strategies to improve vaccination efficacy, achieve long-lasting protective immunity and prevent major infectious diseases of global importance.

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来源期刊

Advances in Immunology 医学-免疫学

CiteScore

9.90

自引率

0.00%

发文量

期刊介绍： Advances in Immunology has provided students and researchers with the latest information in Immunology for over 50 years. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches.