Lymphoepithelioma-like carcinoma of the distal urethra: a case report and management strategies.

Lymphoepithelioma-like carcinoma (LELC) of the urethra is an exceptionally rare and aggressive neoplasm, with limited evidence available to inform optimal management. We present the case of a 63-year-old male diagnosed with high-grade urethral LELC, who presented with locally advanced disease. The patient underwent partial penectomy with bilateral inguinal lymphadenectomy, followed by systemic chemotherapy and immunotherapy. This case underscores the importance of a multidisciplinary approach combining surgical resection with systemic therapy in the management of aggressive urethral malignancies. Given the paucity of literature on urethral LELC, additional case reports are critical to enhance our understanding and to develop evidence-based treatment strategies for this rare entity.