锌和铜金属药物:20年的治疗策略和未来方向。

IF 3.4 4区 医学 Q3 CHEMISTRY, MEDICINAL
Carla Peron, Sidnei Moura
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引用次数: 0

摘要

本文综述了金属药物,即金属与有机分子配位形成的化合物,作为提高治疗效果和解决传统药物局限性的一种有前景的策略。必需金属,如铜和锌,发挥着重要的生物学作用,可以赋予独特的药理学特性,包括改善溶解度,生物活性和选择性,同时潜在地降低毒性。尽管有这些优势,金属药物的建模和表征仍然具有挑战性,因为它们具有可变的氧化态和不同的配位几何形状。先进的技术,如核磁共振波谱、x射线晶体学和质谱,对于阐明它们的结构和功能至关重要。这些药物的未来发展依赖于改进这些方法和实施创新的给药策略,如金属有机框架(MOFs),以创造更安全、更有效的治疗方法。通过战略性地设计金属配体相互作用,金属药物可以实现靶向生物活性并克服耐药机制,将其定位为下一代治疗药物,有可能改变肿瘤、传染病等疾病的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Zinc and copper metallodrugs: a 20-year perspective on therapeutic strategies and future directions.

This review explores the use of metallodrugs, compounds formed by coordinating metals with organic molecules, as a promising strategy to enhance therapeutic efficacy and address the limitations of conventional drugs. Essential metals, such as copper and zinc, play critical biological roles and can impart unique pharmacological properties, including improved solubility, bioactivity, and selectivity, while potentially reducing toxicity. Despite these advantages, modeling and characterizing metallodrugs remains challenging due to their variable oxidation states and diverse coordination geometries. Advanced techniques, such as NMR spectroscopy, X-ray crystallography, and mass spectrometry, are crucial for elucidating their structure and function. The future development of these drugs relies on refining these methodologies and implementing innovative delivery strategies, like metal-organic frameworks (MOFs), to create safer and more effective therapies. By strategically designing metal-ligand interactions, metallodrugs can achieve targeted bioactivity and overcome resistance mechanisms, positioning them as next-generation therapeutics with the potential to transform treatments in oncology, infectious diseases, and beyond.

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来源期刊
Future medicinal chemistry
Future medicinal chemistry CHEMISTRY, MEDICINAL-
CiteScore
5.80
自引率
2.40%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Future Medicinal Chemistry offers a forum for the rapid publication of original research and critical reviews of the latest milestones in the field. Strong emphasis is placed on ensuring that the journal stimulates awareness of issues that are anticipated to play an increasingly central role in influencing the future direction of pharmaceutical chemistry. Where relevant, contributions are also actively encouraged on areas as diverse as biotechnology, enzymology, green chemistry, genomics, immunology, materials science, neglected diseases and orphan drugs, pharmacogenomics, proteomics and toxicology.
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