金(I)催化炔烯酮与六氢嘧啶杂环化/(6 + 3)环加成级联合成新型Cyclonona[c]呋喃骨架。

IF 3.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2025-10-06 DOI:10.1002/asia.70357

Songyi Gao, Xiaoai Liu, Ming Lang, Yu Xiong, Chao Peng, Ye Guo, Shiyong Peng

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引用次数: 0

摘要

报道了一种金(I)催化的炔烯酮与六氢嘧啶之间的杂环化/(6 + 3)环加成级联反应，为在温和条件下以中高产率合成结构新颖的1,5-重氮酮-融合的环状[c]呋喃框架提供了模块化平台。三环和四环产物都可以从环炔烯酮中得到。此外，不对称版本已经在概念验证水平上进行了演示，使用手性h8 - binol衍生的磷酸酰胺配体L7提供50%的ee。

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Synthesis of Novel Cyclonona[c]furan Frameworks via Gold(I)-Catalyzed Heterocyclization/(6 + 3) Cycloaddition Cascade of Yne-enones with Hexahydropyrimidines.

A gold(I)-catalyzed heterocyclization/(6 + 3) cycloaddition cascade between yne-enones and hexahydropyrimidines is reported, offering a modular platform for the synthesis of structurally novel 1,5-diazonane-fused cyclonona[c]furan frameworks in moderate to good yields under mild conditions. Both tricyclic and tetracyclic products are accessible from cyclic yne-enones. Moreover, the asymmetric version has been demonstrated at the proof-of-concept level, delivering 50% ee using the chiral H₈-BINOL-derived phosphoramidite ligand L7.

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).