大麻二酚在口腔疾病中的治疗潜力

IF 3.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of the American Dental Association Pub Date : 2025-10-01 DOI:10.1016/j.adaj.2025.07.021

Lukas Mendes de Abreu DDS, MS, Mariel Ruivo Biancardi DDS, MS, Michele Di Benedetto DDS, Raquel Molina Sanches DDS, Camila Lopes Cardoso DDS, MS, PhD, Cássia Maria Fischer Rubira DDS, MS, PhD, Izabel Regina Fischer Rubira-Bullen DDS, MS, PhD

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引用次数: 0

摘要

本综述旨在评价大麻二酚（CBD）治疗口腔疾病的潜力，重点关注其在治疗口腔面部疼痛、炎症和粘膜病变方面的有效性。本系统评价遵循2020年系统评价和荟萃分析指南的首选报告项目。综合检索了5个数据库，包括随机对照试验和非随机试验，评估CBD对口腔疾病的临床效果。纳入标准由2名审稿人使用预定义的资格参数独立应用。结果在4093份文献中，7项研究符合纳入标准：6项随机对照试验和1项非随机临床研究。局部和口服CBD制剂在减轻疼痛、肌肉紧张、牙龈炎症、细菌负荷和阿弗顿溃疡症状方面具有有益的作用。没有严重的不良反应报告。剂量、配方、随访时间和结果测量的异质性限制了研究间的直接比较，并排除了meta分析。实际意义scbd可作为治疗口腔疼痛和炎症的安全辅助药物。将其纳入牙科保健方案需要通过标准化的长期临床试验进一步验证，以确保疗效和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic potential of cannabidiol in oral disorders

Background

This review aimed to evaluate the therapeutic potential of cannabidiol (CBD) for management of oral disorders, focusing on its effectiveness in treatment (therapy) of orofacial pain, inflammation, and mucosal lesions.

Types of Studies Reviewed

This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. A comprehensive search in 5 databases included randomized controlled trials and nonrandomized trials evaluating CBD’s clinical effects on oral disorders. Inclusion criteria were applied independently by 2 reviewers using predefined eligibility parameters.

Results

Of 4,093 records, 7 studies met inclusion criteria: 6 randomized controlled trials and 1 nonrandomized clinical study. Topical and intraoral CBD formulations had beneficial effects in reducing pain, muscle tension, gingival inflammation, bacterial load, and aphthous ulcer symptoms. No serious adverse effects were reported. Heterogeneity in dosage, formulation, follow-up duration, and outcome measures limited direct comparison across studies and precluded meta-analysis.

Practical Implications

CBD may serve as a safe adjunct in managing oral pain and inflammation. Its integration into dental care protocols requires further validation through standardized, long-term clinical trials to ensure efficacy and safety.

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来源期刊

Journal of the American Dental Association 医学-牙科与口腔外科

CiteScore

5.30

自引率

10.30%

发文量

221

审稿时长

34 days

期刊介绍： There is not a single source or solution to help dentists in their quest for lifelong learning, improving dental practice, and dental well-being. JADA+, along with The Journal of the American Dental Association, is striving to do just that, bringing together practical content covering dentistry topics and procedures to help dentists—both general dentists and specialists—provide better patient care and improve oral health and well-being. This is a work in progress; as we add more content, covering more topics of interest, it will continue to expand, becoming an ever-more essential source of oral health knowledge.