Patrick K Moonan, Stephen O Mathew, Jerry W Simecka, Stephen E Weis
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Restoring TB-specific immunity in early HIV infection—the dual promise of early antiretroviral and TB preventive treatment
Early HIV infection disrupts TB-specific immunity, raising TB risk before CD4 decline. Early ART may help but cannot fully restore function, making tuberculosis preventive treatment indispensable—potentially lifelong—to close immunologic gaps and reduce HIV-associated TB morbidity and mortality.
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