{"title":"HemoCue 201与HemoCue 301在Sysmex自动血液分析仪中检测哈里亚纳邦农村15 ~ 49岁育龄妇女血红蛋白浓度的比较","authors":"Pritam Halder, Shashi Kant, Archana Singh, Ravneet Kaur","doi":"10.4103/ijph.ijph_1405_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anemia is diagnosed based on the hemoglobin (Hb) concentration. Sysmex automated hematology analyzer is accepted as the gold standard technique. The introduction of a digital hemoglobinometer is an important addition of testing device under the Anemia Mukt Bharat program.</p><p><strong>Objectives: </strong>The objectives of this study were to determine the precision and validity of the digital hemoglobinometers in measuring Hb concentration among nonpregnant women of reproductive age who received intravenous iron sucrose (IVIS) for moderate anemia during pregnancy 6 and 12 months ago.</p><p><strong>Materials and methods: </strong>Nonpregnant women of the reproductive age group were recruited from the IVIS register available at two primary health centers in rural Haryana. Paired capillary and venous blood samples were collected simultaneously for the estimation of Hb concentration by digital hemoglobinometers and hematology analyzer, respectively.</p><p><strong>Results: </strong>A total of 150 and 129 participants were included for measuring Hb concentration by HemoCue 201 and HemoCue 301, respectively. Both the digital hemoglobinometers underestimated the Hb concentration compared to the hematology analyzer. The bias (level of agreement) was -0.38 (-1.81-1.04) for HemoCue 201 and -0.15 (-1.19-0.89) for HemoCue 301 compared to hematology analyzer. Lin's concordance coefficient was higher in HemoCue 301 (0.79) than in HemoCue 201 (0.68). Kappa statistics showed strong (0.81) and moderate (0.77) agreement for HemoCue 301 and HemoCue 201, respectively. Both digital hemoglobinometers showed excellent diagnostic precision (AUC of receiver operating characteristic: HemoCue 201: 0.92 [95% confidence interval (CI) 0.86-0.98], and for HemoCue 301: 0.92 [95% CI 0.86-0.97]).</p><p><strong>Conclusion: </strong>Both the digital hemoglobinometers had acceptable precision and validity. Therefore, either of these two digital hemoglobinometers could be used for the screening of anemia.</p>","PeriodicalId":13298,"journal":{"name":"Indian journal of public health","volume":"69 3","pages":"273-279"},"PeriodicalIF":0.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Measurement of Hemoglobin Concentration by HemoCue 201 and HemoCue 301 with Sysmex Automated Hematology Analyzer among Nonpregnant Women of Reproductive Age Group (15-49 Years) in a Rural Area of Haryana.\",\"authors\":\"Pritam Halder, Shashi Kant, Archana Singh, Ravneet Kaur\",\"doi\":\"10.4103/ijph.ijph_1405_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Anemia is diagnosed based on the hemoglobin (Hb) concentration. Sysmex automated hematology analyzer is accepted as the gold standard technique. The introduction of a digital hemoglobinometer is an important addition of testing device under the Anemia Mukt Bharat program.</p><p><strong>Objectives: </strong>The objectives of this study were to determine the precision and validity of the digital hemoglobinometers in measuring Hb concentration among nonpregnant women of reproductive age who received intravenous iron sucrose (IVIS) for moderate anemia during pregnancy 6 and 12 months ago.</p><p><strong>Materials and methods: </strong>Nonpregnant women of the reproductive age group were recruited from the IVIS register available at two primary health centers in rural Haryana. Paired capillary and venous blood samples were collected simultaneously for the estimation of Hb concentration by digital hemoglobinometers and hematology analyzer, respectively.</p><p><strong>Results: </strong>A total of 150 and 129 participants were included for measuring Hb concentration by HemoCue 201 and HemoCue 301, respectively. Both the digital hemoglobinometers underestimated the Hb concentration compared to the hematology analyzer. The bias (level of agreement) was -0.38 (-1.81-1.04) for HemoCue 201 and -0.15 (-1.19-0.89) for HemoCue 301 compared to hematology analyzer. Lin's concordance coefficient was higher in HemoCue 301 (0.79) than in HemoCue 201 (0.68). Kappa statistics showed strong (0.81) and moderate (0.77) agreement for HemoCue 301 and HemoCue 201, respectively. Both digital hemoglobinometers showed excellent diagnostic precision (AUC of receiver operating characteristic: HemoCue 201: 0.92 [95% confidence interval (CI) 0.86-0.98], and for HemoCue 301: 0.92 [95% CI 0.86-0.97]).</p><p><strong>Conclusion: </strong>Both the digital hemoglobinometers had acceptable precision and validity. Therefore, either of these two digital hemoglobinometers could be used for the screening of anemia.</p>\",\"PeriodicalId\":13298,\"journal\":{\"name\":\"Indian journal of public health\",\"volume\":\"69 3\",\"pages\":\"273-279\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian journal of public health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/ijph.ijph_1405_23\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/10/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of public health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/ijph.ijph_1405_23","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/4 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Comparison of Measurement of Hemoglobin Concentration by HemoCue 201 and HemoCue 301 with Sysmex Automated Hematology Analyzer among Nonpregnant Women of Reproductive Age Group (15-49 Years) in a Rural Area of Haryana.
Background: Anemia is diagnosed based on the hemoglobin (Hb) concentration. Sysmex automated hematology analyzer is accepted as the gold standard technique. The introduction of a digital hemoglobinometer is an important addition of testing device under the Anemia Mukt Bharat program.
Objectives: The objectives of this study were to determine the precision and validity of the digital hemoglobinometers in measuring Hb concentration among nonpregnant women of reproductive age who received intravenous iron sucrose (IVIS) for moderate anemia during pregnancy 6 and 12 months ago.
Materials and methods: Nonpregnant women of the reproductive age group were recruited from the IVIS register available at two primary health centers in rural Haryana. Paired capillary and venous blood samples were collected simultaneously for the estimation of Hb concentration by digital hemoglobinometers and hematology analyzer, respectively.
Results: A total of 150 and 129 participants were included for measuring Hb concentration by HemoCue 201 and HemoCue 301, respectively. Both the digital hemoglobinometers underestimated the Hb concentration compared to the hematology analyzer. The bias (level of agreement) was -0.38 (-1.81-1.04) for HemoCue 201 and -0.15 (-1.19-0.89) for HemoCue 301 compared to hematology analyzer. Lin's concordance coefficient was higher in HemoCue 301 (0.79) than in HemoCue 201 (0.68). Kappa statistics showed strong (0.81) and moderate (0.77) agreement for HemoCue 301 and HemoCue 201, respectively. Both digital hemoglobinometers showed excellent diagnostic precision (AUC of receiver operating characteristic: HemoCue 201: 0.92 [95% confidence interval (CI) 0.86-0.98], and for HemoCue 301: 0.92 [95% CI 0.86-0.97]).
Conclusion: Both the digital hemoglobinometers had acceptable precision and validity. Therefore, either of these two digital hemoglobinometers could be used for the screening of anemia.
期刊介绍：
Indian Journal of Public Health is a peer-reviewed international journal published Quarterly by the Indian Public Health Association. It is indexed / abstracted by the major international indexing systems like Index Medicus/MEDLINE, SCOPUS, PUBMED, etc. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles. The Indian Journal of Public Health publishes articles of authors from India and abroad with special emphasis on original research findings that are relevant for developing country perspectives including India. The journal considers publication of articles as original article, review article, special article, brief research article, CME / Education forum, commentary, letters to editor, case series reports, etc. The journal covers population based studies, impact assessment, monitoring and evaluation, systematic review, meta-analysis, clinic-social studies etc., related to any domain and discipline of public health, specially relevant to national priorities, including ethical and social issues. Articles aligned with national health issues and policy implications are prefered.
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