可见光诱导下脱羧糖基化合成吲哚/苯并咪唑[2,1-a]异喹啉衍生物

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-09-26 DOI:10.1016/j.tet.2025.134956

Xueqin Wang, Xingqin Tian, Penghua Zhang, Jing Zhang, Fang Ye, Guanghui Lv

引用次数: 0

摘要

采用糖基NHP酯建立了可见光诱导n -甲基丙烯酰-2-苯基吲哚/苯并咪唑的级联自由基环化反应。该方案为糖基取代吲哚/苯并咪唑[2,1-a]异喹啉的合成提供了一种高效实用的方法，收率高，反应条件温和，底物范围广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-light-induced synthesis of indolo/benzimidazo[2,1-a]isoquinoline derivatives via decarboxylative glycosylation

查看原文本刊更多论文

Visible-light-induced synthesis of indolo/benzimidazo[2,1-a]isoquinoline derivatives via decarboxylative glycosylation

A visible-light-induced cascade radical cyclization process of N-methacryloyl-2-phenyl indolo/benzimidazole has been established with glycosyl NHP esters. This protocol provides an efficient and practical method for the synthesis of glycosyl-substituted indolo/benzimidazo[2,1-a]isoquinoline in outstanding yields, mild reaction conditions and broad substrate scope.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.