Assessment of Insulin Resistance in Different Phases of Bipolar Disorder with Triglyceride Glucose Index (TyG), Triglyceride Glucose-Body Mass Index (TyG-BMI) and Metabolic Score Index for Insulin Resistance (METS-IR).

Objective: The aim of this study was to determine whether there are differences in the parameters Triglyceride Glucose Index (TyG), Triglyceride Glucose-Body Mass Index (TyG-BMI) and Metabolic Score Index for Insulin Resistance (METS-IR) between the groups of patients diagnosed with Bipolar disorder (BD) in euthymic, manic and depressive states and healthy controls.

Methods: A total of 238 patients diagnosed with BD, and 90 healthy controls were included in the study.

Results: TyG-BMI was higher in depressed state BD patients than in manic state BD patients. The METS-IR was significantly higher in depressed BD patients than in healthy controls. TyG-BMI was a statistically significant predictor for euthymic and depressed states of BD. In addition, the METS-IR was a statistically significant predictor for the euthymic state BD, depressed state BD and whole BD patient group. In the ROC analysis, we obtained the highest AUC values in the parameters TyG-BMI and METS-IR to discriminate the patient groups from healthy controls.

Conclusion: Our results are noteworthy as the first study to provide evidence that elevated levels of METS-IR and TyG-BMI may be an indicator of IR in BD patients and can be used to differentiate BD patients from healthy controls. However, there is a need for confirmation of these results in larger studies before definitive conclusions are possible.