急性Marchiafava-Bignami病累及整个胼胝体和弥漫性白质。

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-10-04 DOI:10.1007/s10072-025-08560-6

Jieqiang Xia, Qing Lin, Xue Ke

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引用次数: 0

摘要

急性marchiafva - bignami病（MBD）可扩展到胼胝体以外的弥漫性半球白质，预示着不良的预后。我们报告了一位57岁的长期酗酒的男性，他出现了虚弱和昏迷。磁共振成像（MRI）在t2加权成像(T2WI)/液体衰减反转恢复（FLAIR）和弥散加权成像（DWI）上显示贯穿胼胝体和胼胝体外白质的高强度、肿胀病变，与细胞毒性水肿一致。尽管及时给予大剂量硫胺素和积极的支持治疗，他还是在几天内死亡。本病例强调了DWI对急性MBD的早期发现和预后的诊断价值，并强调了对慢性酒精滥用背景的昏迷患者进行紧急脑MRI的重要性。

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Entire corpus callosum and diffuse white matter involvement in acute Marchiafava-Bignami disease.

Acute Marchiafava-Bignami disease (MBD) can extend beyond the corpus callosum to diffuse hemispheric white matter, portending poor outcomes. We report a 57-year-old man with long-standing alcohol abuse who developed weakness and coma. Magnetic resonance imaging (MRI) revealed hyperintense, swollen lesions throughout the corpus callosum and extracallosal white matter on T2-weighted imaging (T2WI)/fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging(DWI), consistent with cytotoxic edema. Despite prompt high-dose thiamine and aggressive supportive care, he died within days. This case underscores the diagnostic value of DWI for early detection and prognostication in acute MBD, and highlights the importance of urgent brain MRI in comatose patients with a background of chronic alcohol abuse.

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.