巨噬细胞极化在糖尿病血管并发症中的作用机制和治疗靶点。

IF 7.5 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Liyuan Cao, Lu Ding, Qinjing Xia, Zepeng Zhang, Min Li, Siyu Song, Kai Yin, Zirui Li, Xueyan Li, Zihan Wang, Daqing Zhao, Xiangyan Li, Zeyu Wang
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引用次数: 0

摘要

糖尿病,尤其是2型糖尿病,是一种广泛存在的慢性代谢性疾病,其特征是持续高血糖和低度慢性炎症。这种持续的炎症状态是大血管和微血管并发症的主要驱动因素。在免疫细胞中,巨噬细胞作为慢性炎症的效应器和调节剂发挥着核心作用。在糖尿病环境中,它们对不同的微环境信号作出反应,并分化成不同的功能表型,从而促进糖尿病相关血管损伤的进展和潜在的解决。本文综述了巨噬细胞极化在糖尿病血管并发症中的机制,阐明了关键信号通路及其与代谢功能障碍的相互作用,并总结了目前的调控策略和新兴的治疗靶点。特别强调的是最近的调节巨噬细胞极化的药理学方法,强调它们作为延迟或预防糖尿病血管并发症发生和进展的新策略的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Macrophage polarization in diabetic vascular complications: mechanistic insights and therapeutic targets.

Diabetes mellitus, particularly type 2 diabetes mellitus, is a widespread chronic metabolic disorder characterized by persistent hyperglycemia and low-grade chronic inflammation. This sustained inflammatory state is a major driver of both macrovascular and microvascular complications. Among immune cells, macrophages play a central role as effectors and regulators of chronic inflammation. In the diabetic milieu, they respond to diverse microenvironmental cues and polarize into distinct functional phenotypes, thereby contributing to both the progression and potential resolution of diabetes-associated vascular damage. This review examines the mechanisms of macrophage polarization in diabetic vascular complications, elucidates key signaling pathways and their interactions with metabolic dysfunction, and summarizes current regulatory strategies and emerging therapeutic targets. Particular emphasis is placed on recent pharmacological approaches that modulate macrophage polarization, highlighting their potential as novel strategies to delay or prevent the onset and progression of vascular complications in diabetes.

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来源期刊
Journal of Translational Medicine
Journal of Translational Medicine 医学-医学:研究与实验
CiteScore
10.00
自引率
1.40%
发文量
537
审稿时长
1 months
期刊介绍: The Journal of Translational Medicine is an open-access journal that publishes articles focusing on information derived from human experimentation to enhance communication between basic and clinical science. It covers all areas of translational medicine.
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