破解神经胶质瘤易感性。

IF 19.1 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-10-03 DOI:10.1038/s41556-025-01782-y

Andrea Fratton, Boyan Bonev

引用次数: 0

摘要

在胶质瘤中驱动癌基因表达的调控机制仍然知之甚少。一项研究现在确定了增强子连接体广泛重排的作用。这种重排与已知的遗传风险变异有关，揭示了遗传易感性是如何导致恶性肿瘤的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Deciphering glioma susceptibility

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Deciphering glioma susceptibility

The regulatory mechanisms that drive oncogene expression in gliomas remain poorly understood. A study now identifies a role for widespread rearrangements of the enhancer connectome. Such rearrangements are linked to known genetic risk variants, revealing how genetic predisposition contributes to malignancy.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology