嗅觉(SoS)图谱:它的创建和首次应用,以全面定量MRI协议研究与COVID-19相关的嗅觉缺失。

IF 3.5 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Marta Gaviraghi, Eleonora Lupi, Elena Grosso, Andrea Fusari, Mattia Baiguera, Anita Monteverdi, Marco Battiston, Francesco Grussu, Baris Kanber, Ferran Prados Carrasco, Rebecca S Samson, Janine Makaronidis, Marios C Yiannakas, Michael S Zandi, Rachel L Batterham, Egidio D'Angelo, Fulvia Palesi, Claudia A M Gandini Wheeler-Kingshott
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引用次数: 0

摘要

背景:包括COVID-19在内的许多疾病都注意到嗅觉丧失(嗅觉缺失)。炎症和显微结构改变可能是COVID-19嗅觉缺失的潜在机制。然而,目前还没有研究嗅觉和相关组织特性变化的图谱。目的:建立包括嗅觉回路灰质区和白质束在内的嗅觉图谱,探讨与COVID-19相关的嗅觉缺失的基础。研究类型:回顾性。研究对象:SoS图谱使用了人类连接组计划10名健康对照(HC)(7名女性,22-35岁)的高分辨率神经束图。SoS图谱应用于8例COVID-19术后持续嗅觉缺失患者(COVID-P, 7例女性,52±12岁)、19例COVID-19术后嗅觉缺失恢复患者(COVID-R, 14例女性,38±13岁)和17例HC患者(8例女性,39±12岁)。场强/序列:3t、三维反演恢复、三维快速场回波、自旋回波回波平面成像序列。评估:为了创建SoS图谱,根据生物学限制,通过神经束造影确定区域并提取神经束。对神经炎症、轴突变性、髓磷脂和大分子密度以及铁敏感的MRI指标进行了分析。统计检验:基于区域的分析(p值)结果:SoS图谱由35个区域组成,经过解剖整理,最初的506个束被细化到78个。与HC相比,COVID-P表现出神经炎症相关(平均占总改变的41%)和轴突变性相关(31%)MRI指标的改变,而COVID-R表现出髓磷脂相关指标的改变(68%)。COVID-P变异主要影响后脑(56%),而COVID-R变异主要影响后脑(39%)。数据结论:我们开发了一种新的工具SoS图谱来研究嗅觉系统,并将其与多序列mri指标相结合来研究COVID-19相关嗅觉缺失的机制。证据等级:3。技术功效:第一阶段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Sense of Smell (SoS) Atlas: Its Creation and First Application to Investigate COVID-19 Related Anosmia With a Comprehensive Quantitative MRI Protocol.

Background: The loss of smell (anosmia) has been noted in numerous diseases, including COVID-19. Inflammatory and microstructural alterations are possible underlying mechanisms of anosmia in COVID-19. However, no atlas exists to study olfaction and the associated tissue property changes.

Purpose: To develop the sense of smell (SoS) atlas, including gray matter regions and white matter tracts of the olfactory circuit, to investigate the underpinnings of COVID-19 related anosmia.

Study type: Retrospective.

Subjects: For the SoS atlas, high-resolution tractograms of 10 healthy controls (HC) of the Human Connectome Project (7 females, 22-35 years) were used. The SoS atlas was applied to 8 subjects with persistent anosmia following COVID-19 (COVID-P, 7 females, 52 ± 12 years), 19 subjects that recovered from COVID-19 anosmia (COVID-R, 14 females, 38 ± 13 years), and 17 HC (8 females, 39 ± 12 years).

Field strength/sequence: 3 T, 3D inversion recovery, 3D fast field echo, and spin-echo echo-planar imaging sequences.

Assessment: To create the SoS atlas, regions were identified and tracts were extracted via tractography following biological constraints. MRI metrics sensitive to alterations in neuroinflammation, axonal degeneration, myelin and macromolecular density, and iron were analyzed.

Statistical tests: Region-based analysis (p-value < 0.05, false discovery rate (FDR) corrected) and voxel-based analysis (p-value < 0.001 uncorrected, FDR-corrected cluster extent = 5 voxels) were performed on 15 multisequence-MRI metrics between the three groups.

Results: The SoS atlas consisted of 35 regions and, after anatomical curation, the initial 506 tracts were refined to 78. Compared to HC, COVID-P presented alterations in neuroinflammation-related (mean: 41% of total alterations) and axonal degeneration-related (31%) MRI metrics, while COVID-R presented alterations of myelin-related metrics (68%). COVID-P alterations mainly affected the hindbrain (56%), while COVID-R the hindbrain (39%).

Data conclusion: A novel tool, the SoS atlas, was developed to study the olfactory system and applied in combination with multisequence-MRI metrics to investigate the mechanisms of COVID-19 related anosmia.

Evidence level: 3.

Technical efficacy: Stage 1.

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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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