年轻健康成人侧脑室大小、脑脊液动力学和导水管阻力的关系

IF 3.5 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Pan Liu, Jiachen Xie, Kimi Owashi, Yann Attekeble, Jean-Marc Constans, Cyrille Capel, Olivier Balédent
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引用次数: 0

摘要

背景:脑室增大和脑脊液循环异常与交通性脑积水(NPH)密切相关,但其因果关系尚不清楚。研究健康人群可能有助于阐明这些机制。现有的脑脊液动力学和心室形态学指标受到心率和脑大小等生理变异性的限制,而在健康人群中对输水管阻力的研究很少。目的:量化健康人群输水管阻力及输水管与颈区脑脊液脑卒中容积比(ratio- sv)和侧脑室与总脑面积比(ratio- area)两项比率指标,并探讨其相互关系。研究类型:前瞻性。人群:健康青壮年34人(女性17人,男性17人,年龄25.2±3.9岁);4例NPH患者(女2例,男2例,年龄50-80岁)。场强/序列:3t MRI,横向三维t1加权梯度回波,矢状面三维平衡快速场回波(BFFE;梯度回波),2D CINE相衬(CINE- pc;梯度回波)序列。评价:采用BFFE、t1加权像的Ratio-Area和CINE-PC的Ratio-SV分别测量输水管阻力。性别差异也被研究。统计学检验:组间比较采用Wilcoxon检验,各参数间相关性采用Spearman相关,p。结果:健康成人平均导水管阻力为72±42 mPa s/mm3, Ratio-SV为6.0%±2.3%,Ratio-Area为4.5%±1.6%。男性的Ratio-Area明显低于女性(3.9%±1.3% vs. 5.2%±1.7%)。Ratio-SV不受心动周期影响。渡槽阻力与Ratio-SV呈显著负相关(r = -0.65),与Ratio-Area无显著相关(r = -0.27)。Ratio-SV和Ratio-Area也不相关(r = 0.08)。数据结论:基于比率的指标通过减少生理变化的影响,为评估心室形态和脑脊液动力学提供了有用的参数。结合输水管阻力,这些健康成人的基线数据可能有助于更好地理解NPH的病理生理学。证据等级:2。技术功效:第一阶段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationships Between Lateral Ventricle Size, Cerebrospinal Fluid Dynamics, and Aqueductal Resistance in Young Healthy Adults.

Background: Ventricular enlargement and abnormal cerebrospinal fluid (CSF) circulation are closely associated in communicating hydrocephalus (NPH), yet their causal relationship remains unclear. Studying healthy populations may help clarify these mechanisms. Existing metrics for CSF dynamics and ventricular morphology are limited by physiological variability such as heart rate and brain size, and aqueductal resistance has been little studied in healthy cohorts.

Purpose: To quantify aqueductal resistance and two ratio-based indices-the CSF stroke volume ratio of the aqueduct to the cervical region (Ratio-SV) and the lateral ventricle to total brain area ratio (Ratio-Area)-in a healthy population, and to examine their interrelationships.

Study type: Prospective.

Population: 34 healthy young adults (17 female, 17 male; age, 25.2 ± 3.9 years old); 4 NPH patients (2 female, 2 male; age, 50-80 years old).

Field strength/sequence: 3 T MRI with transverse 3D T1-weighted gradient echo, sagittal 3D Balanced Fast Field Echo (BFFE; gradient echo), and 2D CINE Phase Contrast (CINE-PC; gradient echo) sequences.

Assessment: Aqueductal resistance was measured on BFFE, Ratio-Area on T1-weighted images, and Ratio-SV on CINE-PC. Sex differences were also examined.

Statistical tests: Wilcoxon test was used for group comparisons, and Spearman's correlation for associations among parameters, with p < 0.05 considered significant.

Results: In healthy adults, mean aqueductal resistance was 72 ± 42 mPa s/mm3, Ratio-SV 6.0% ± 2.3% and Ratio-Area 4.5% ± 1.6%. Males exhibited a significantly lower Ratio-Area compared to females (3.9% ± 1.3% vs. 5.2% ± 1.7%). Ratio-SV was unaffected by the cardiac cycle. Aqueductal resistance showed a strong negative correlation with Ratio-SV (r = -0.65) but showed no significant correlation with Ratio-Area (r = -0.27). Ratio-SV and Ratio-Area were also uncorrelated (r = 0.08).

Data conclusion: Ratio-based metrics provide useful parameters for evaluating both ventricular morphology and CSF dynamics by reducing the influence of physiological variations. Combined with aqueductal resistance, these baseline data in healthy adults may contribute to a better understanding of the pathophysiology of NPH.

Evidence level: 2.

Technical efficacy: Stage 1.

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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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