Therapeutic and Diagnostic Perspectives for Advancing Spaceflight Dermatology.

Introduction: As international efforts in space exploration continue, spaceflight dermatology is a critical field for ensuring the health of astronauts. Microgravity, limited hygiene, and radiation uniquely impair skin integrity, contributing to issues such as dermal atrophy, xerosis, and increased infection risk during spaceflight. This commentary highlights practical strategies and potential research avenues for preventing and addressing the array of dermatologic changes during spaceflight. There are multiple promising interventions, including retinoids, vitamin-A derivatives, calcitriol, L-asparaginase, advanced dressings, telemedicine, and immune-system enhancement strategies which may help mitigate skin-thinning, dermatitis, and slow wound-healing. Continued interdisciplinary collaboration, more human data, and real-time data collection will refine and validate strategies, improving skin health in space. Routine consideration of novel dermatologic therapies may benefit spaceflight and overall mission success as humans venture farther into space. Henke J, Kamboj S, Barrett D, Idris H, Gangal A, Blalock T. Therapeutic and diagnostic perspectives for advancing spaceflight dermatology. Aerosp Med Hum Perform. 2025; 96(10):947-949.