Yuan-Hai Sun, Ya-Qian Feng, Sun-Ying Cheng, Ling-Huan Li, Han-Bing Li
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引用次数: 0
摘要
脂肪组织产热，既包括解偶联蛋白1 （uncoupling protein 1, UCP1）依赖性产热，也包括非依赖性产热，在全身代谢的稳态中起关键作用。新的证据表明，脂肪组织产热的关键节点可以通过动态和可逆的n6 -甲基腺苷（m6A）修饰来调节，这是最普遍和广泛研究的RNA修饰之一。此外，它的失调驱动肥胖和相关代谢紊乱的发病机制。本文综述了m6A修饰在脂肪组织产热中的作用及分子机制，重点阐述了靶向m6A修饰促进脂肪组织产热重塑的潜在治疗策略，并讨论了该领域未来的研究方向。这些见解为旨在开发基于m6的代谢性疾病疗法的转化研究提供了线索。
An Insight Into Adipose Tissue Thermogenesis Regulated by N6-Methyladenosine: Mechanisms and Therapeutic Implications.
Adipose tissue thermogenesis, both uncoupling protein 1 (UCP1)-dependent and independent thermogenesis, plays a critical role in the homeostasis of whole-body metabolism. Emerging evidence demonstrates that key nodes in adipose tissue thermogenesis can be regulated by dynamic and reversible N6-methyladenosine (m6A) modification, which is one of the most prevalent and extensively studied RNA modifications. Furthermore, its dysregulation drives the pathogenesis of obesity and related metabolic disorders. In this review, we elucidate the role and molecular mechanisms of m6A modification in adipose tissue thermogenesis, highlight potential therapeutic strategies for promoting thermogenic remodeling of adipose tissue through targeting m6A modification, and discuss future research directions in this field. The insights provide clues for translational research aimed at developing m6A-based therapies for metabolic diseases.
期刊介绍：
Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities.
Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field.
The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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