{"title":"成人发病的部分单侧黄斑病:一种罕见的色素镶嵌病,对氨甲环酸有临床反应","authors":"Niranjan Pudasaini, Sabin Poudel, Aashutosh Pokharel, Anup Mishra, Anil Kumar Singh Dangol, Manisha Chapagain","doi":"10.1002/ccr3.71113","DOIUrl":null,"url":null,"abstract":"<p>Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder characterized by numerous lentigines grouped within normal skin in a segmental pattern with sharp demarcation at the midline. The authors hereby present a case of a 40-year-old female, who presented with multiple asymptomatic, gradually progressive, brownish flat skin lesions on her left breast, abdomen, and left half of the trunk for 16 years. Diagnosis was made clinically via properly documented history, physical examination, and histopathological evaluation. Although treatment is unnecessary, many patients seek consultations for cosmetic reasons. Our patient is showing a good response to the prescribed tablet tranexamic acid and topical kojic acid cream, along with regular application of sun protection cream SPF 50+. This is a rare case of adult-onset PUL showing good clinical improvement with oral tranexamic acid combined with kojic acid cream.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71113","citationCount":"0","resultStr":"{\"title\":\"Adult-Onset Partial Unilateral Lentiginosis: A Rare Pigmentary Mosaicism With Clinical Response to Tranexamic Acid\",\"authors\":\"Niranjan Pudasaini, Sabin Poudel, Aashutosh Pokharel, Anup Mishra, Anil Kumar Singh Dangol, Manisha Chapagain\",\"doi\":\"10.1002/ccr3.71113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder characterized by numerous lentigines grouped within normal skin in a segmental pattern with sharp demarcation at the midline. The authors hereby present a case of a 40-year-old female, who presented with multiple asymptomatic, gradually progressive, brownish flat skin lesions on her left breast, abdomen, and left half of the trunk for 16 years. Diagnosis was made clinically via properly documented history, physical examination, and histopathological evaluation. Although treatment is unnecessary, many patients seek consultations for cosmetic reasons. Our patient is showing a good response to the prescribed tablet tranexamic acid and topical kojic acid cream, along with regular application of sun protection cream SPF 50+. This is a rare case of adult-onset PUL showing good clinical improvement with oral tranexamic acid combined with kojic acid cream.</p>\",\"PeriodicalId\":10327,\"journal\":{\"name\":\"Clinical Case Reports\",\"volume\":\"13 10\",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71113\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ccr3.71113\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ccr3.71113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Adult-Onset Partial Unilateral Lentiginosis: A Rare Pigmentary Mosaicism With Clinical Response to Tranexamic Acid
Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder characterized by numerous lentigines grouped within normal skin in a segmental pattern with sharp demarcation at the midline. The authors hereby present a case of a 40-year-old female, who presented with multiple asymptomatic, gradually progressive, brownish flat skin lesions on her left breast, abdomen, and left half of the trunk for 16 years. Diagnosis was made clinically via properly documented history, physical examination, and histopathological evaluation. Although treatment is unnecessary, many patients seek consultations for cosmetic reasons. Our patient is showing a good response to the prescribed tablet tranexamic acid and topical kojic acid cream, along with regular application of sun protection cream SPF 50+. This is a rare case of adult-onset PUL showing good clinical improvement with oral tranexamic acid combined with kojic acid cream.
期刊介绍:
Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).