体积孔隙率和表面粗糙度对SLM法制备TPMS陀螺结构生物相容性影响的研究

IF 4 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Ki-Seong Park, HoLim Jin, Yoon-A Shin, Aman Gupta, Jae-Kwan Kim, Hui-Nam Rhee, Young-Jin Son, Shi-Hoon Choi
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引用次数: 0

摘要

本研究定量评价了体积孔隙率和平均表面粗糙度对曲面的影响。在本研究中,我们通过定量线性回归分析研究了选择性激光熔化制备的tpms基陀螺结构的体积孔隙率和表面粗糙度对各种生物相容性因子的影响。结果表明,体积孔隙度和表面粗糙度以不同的互补方式影响生物相容性参数。体积孔隙度与成骨相关因子,包括成骨细胞活性、BMM、ALP-p和OPG表现出很强的相关性(R2 > 0.9),表明其在促进细胞粘附、增殖和早期成骨中起关键作用。与OPG的高相关性表明,体积孔隙度通过培养有利的微环境对骨组织的稳定性和再生有重要贡献。相反,骨吸收相关标志物(RANKL)和晚期成骨标志物(OCL)与体积孔隙度的相关性相对较低,表明其主要影响早期成骨过程。相反,表面粗糙度与骨吸收相关标志物(RANKL)和晚期成骨标志物(OCL)表现出很强的相关性(R2 > 0.9)。这突出了曲面特征在调节骨重塑过程中的重要性。与OCL的强相关性(R2 > 0.98)强调了表面粗糙度在调节晚期成骨中的作用,而与ALP-p和OPG的中度相关性(0.38 < R2 < 0.53)表明对早期成骨的影响有限。这些发现表明,体积孔隙度和表面粗糙度在生物相容性中起着互补的作用。体积孔隙度通过提供扩大的表面积和优化的孔隙结构来增强成骨和组织的稳定性,而表面粗糙度直接影响骨吸收和后期细胞活动,特别是在弯曲的表面。整体孔隙率和表面粗糙度作为设计参数的集成对于优化骨形成和骨吸收之间的平衡至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Study on the Effect of Bulk Porosity and Surface Roughness on the Biocompatibility of TPMS Gyroid Structures Fabricated via the SLM Process

A Study on the Effect of Bulk Porosity and Surface Roughness on the Biocompatibility of TPMS Gyroid Structures Fabricated via the SLM Process

This study quantitatively evaluated the effects of bulk porosity and the average surface roughness on curved surfaces. In this study, we investigate the effects of bulk porosity and surface roughness of TPMS-based Gyroid structures fabricated via selective laser melting on various biocompatibility factors through quantitative linear regression analysis. The results demonstrate that bulk porosity and surface roughness influence biocompatibility parameters in distinct and complementary ways. Bulk porosity exhibited a strong correlation (R2 > 0.9) with osteogenesis-related factors, including osteoblastic cell activity, BMM, ALP-p, and OPG, indicating its critical role in promoting cell adhesion, proliferation, and early-stage osteogenesis. The high correlation with OPG suggests that bulk porosity contributes significantly to bone tissue stability and regeneration by fostering a conducive microenvironment. Conversely, resorption-related markers (RANKL) and late-stage osteogenesis markers (OCL) showed relatively low correlations with bulk porosity, indicating its primary influence on early osteogenesis processes. In contrast, surface roughness demonstrated strong correlations (R2 > 0.9) with resorption-related markers (RANKL) and late-stage osteogenesis markers (OCL). This highlights the importance of curved surface characteristics in modulating bone remodeling processes. The strong correlation with OCL (R2 > 0.98) underscores the role of surface roughness in regulating late-stage osteogenesis, while moderate correlations with ALP-p and OPG (0.38 < R2 < 0.53) suggest a limited impact on early-stage osteogenesis. These findings reveal that bulk porosity and surface roughness play complementary roles in biocompatibility. Bulk porosity enhances osteogenesis and tissue stability by providing expanded surface area and optimized pore structures, whereas surface roughness directly influences bone resorption and late-stage cellular activity, particularly on curved surfaces. The integration of bulk porosity and surface roughness as design parameters is crucial for optimizing the balance between bone formation and resorption.

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来源期刊
Metals and Materials International
Metals and Materials International 工程技术-材料科学:综合
CiteScore
7.10
自引率
8.60%
发文量
197
审稿时长
3.7 months
期刊介绍: Metals and Materials International publishes original papers and occasional critical reviews on all aspects of research and technology in materials engineering: physical metallurgy, materials science, and processing of metals and other materials. Emphasis is placed on those aspects of the science of materials that are concerned with the relationships among the processing, structure and properties (mechanical, chemical, electrical, electrochemical, magnetic and optical) of materials. Aspects of processing include the melting, casting, and fabrication with the thermodynamics, kinetics and modeling.
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