Solid pseudopapillary epithelial neoplasm of the pancreatic head: A case report of an atypical site for a rare tumor

Solid pseudopapillary epithelial neoplasms (SPENs) are rare pancreatic tumors, primarily affecting young women and typically located in the pancreatic tail. Occurrence in the pancreatic head is uncommon. Clinical presentation is often asymptomatic, though some patients may develop vague abdominal pain or a gradually enlarging abdominal mass. In head lesions, obstructive jaundice may also occur. SPENs are considered low-grade malignant tumors with potential for local invasion and distant metastasis, most commonly to the liver and omentum. As they lack specific tumor markers, cross-sectional imaging is crucial for diagnosis and surgical planning. Resection remains the mainstay of treatment, with excellent outcomes and 5-year survival rates approaching 97%. We present a rare case of SPEN arising in the pancreatic head, successfully treated with a Whipple’s procedure.