Kamrun Nahar Fatema , Longlong Li , Khurshid Ahmad , Jongyun Kim , Dong-Weon Lee
{"title":"具有可调孔隙度的水凝胶集成仿生羟基磷灰石支架,增强姜黄素的输送","authors":"Kamrun Nahar Fatema , Longlong Li , Khurshid Ahmad , Jongyun Kim , Dong-Weon Lee","doi":"10.1016/j.jddst.2025.107572","DOIUrl":null,"url":null,"abstract":"<div><div>Bone disorders affect nearly 50 % of adults over 50, with severe injuries often surpassing natural healing capacity. While hydroxyapatite (HA)-based scaffolds have shown promise in bone tissue engineering, their effectiveness is limited by brittleness, poor mechanical properties, and inconsistent drug release. To overcome these limitations, we developed a porous biomimetic scaffold with over 70 % porosity, integrating a pH-responsive hydrogel composed of polyacrylic acid, sodium alginate, carboxymethyl cellulose, potato starch, and propyl gallate (PSCPP). This scaffold is designed to stably encapsulate curcumin within hydroxyapatite, addressing these challenges. The system delivers curcumin with dual-phase kinetics: a rapid release in acidic inflammatory environments (pH 5.4) and a transition to sustained release at physiological pH (7.4). Experimental results show a release rate of 3 % over 7 days at neutral pH compared to a 90 % cumulative release at acidic pH, confirming its pH-responsive behavior. Key innovations include PG-stabilized curcumin with starch-modulated release, PSCPP hydrogel optimizing pH responsiveness and swelling, and HA-hydrogel hybridization that preserves bioactivity while enhancing mechanical strength. In vitro studies confirm the scaffold's biocompatibility with over 80 % cell viability. This design combines mechanical stability with controlled drug delivery, demonstrating effective features for bone scaffold applications where both structural support and therapeutic release are needed.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107572"},"PeriodicalIF":4.9000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hydrogel-integrated biomimetic hydroxyapatite scaffolds with tunable porosity for enhanced curcumin delivery\",\"authors\":\"Kamrun Nahar Fatema , Longlong Li , Khurshid Ahmad , Jongyun Kim , Dong-Weon Lee\",\"doi\":\"10.1016/j.jddst.2025.107572\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Bone disorders affect nearly 50 % of adults over 50, with severe injuries often surpassing natural healing capacity. While hydroxyapatite (HA)-based scaffolds have shown promise in bone tissue engineering, their effectiveness is limited by brittleness, poor mechanical properties, and inconsistent drug release. To overcome these limitations, we developed a porous biomimetic scaffold with over 70 % porosity, integrating a pH-responsive hydrogel composed of polyacrylic acid, sodium alginate, carboxymethyl cellulose, potato starch, and propyl gallate (PSCPP). This scaffold is designed to stably encapsulate curcumin within hydroxyapatite, addressing these challenges. The system delivers curcumin with dual-phase kinetics: a rapid release in acidic inflammatory environments (pH 5.4) and a transition to sustained release at physiological pH (7.4). Experimental results show a release rate of 3 % over 7 days at neutral pH compared to a 90 % cumulative release at acidic pH, confirming its pH-responsive behavior. Key innovations include PG-stabilized curcumin with starch-modulated release, PSCPP hydrogel optimizing pH responsiveness and swelling, and HA-hydrogel hybridization that preserves bioactivity while enhancing mechanical strength. In vitro studies confirm the scaffold's biocompatibility with over 80 % cell viability. This design combines mechanical stability with controlled drug delivery, demonstrating effective features for bone scaffold applications where both structural support and therapeutic release are needed.</div></div>\",\"PeriodicalId\":15600,\"journal\":{\"name\":\"Journal of Drug Delivery Science and Technology\",\"volume\":\"114 \",\"pages\":\"Article 107572\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug Delivery Science and Technology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S177322472500975X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Delivery Science and Technology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S177322472500975X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Hydrogel-integrated biomimetic hydroxyapatite scaffolds with tunable porosity for enhanced curcumin delivery
Bone disorders affect nearly 50 % of adults over 50, with severe injuries often surpassing natural healing capacity. While hydroxyapatite (HA)-based scaffolds have shown promise in bone tissue engineering, their effectiveness is limited by brittleness, poor mechanical properties, and inconsistent drug release. To overcome these limitations, we developed a porous biomimetic scaffold with over 70 % porosity, integrating a pH-responsive hydrogel composed of polyacrylic acid, sodium alginate, carboxymethyl cellulose, potato starch, and propyl gallate (PSCPP). This scaffold is designed to stably encapsulate curcumin within hydroxyapatite, addressing these challenges. The system delivers curcumin with dual-phase kinetics: a rapid release in acidic inflammatory environments (pH 5.4) and a transition to sustained release at physiological pH (7.4). Experimental results show a release rate of 3 % over 7 days at neutral pH compared to a 90 % cumulative release at acidic pH, confirming its pH-responsive behavior. Key innovations include PG-stabilized curcumin with starch-modulated release, PSCPP hydrogel optimizing pH responsiveness and swelling, and HA-hydrogel hybridization that preserves bioactivity while enhancing mechanical strength. In vitro studies confirm the scaffold's biocompatibility with over 80 % cell viability. This design combines mechanical stability with controlled drug delivery, demonstrating effective features for bone scaffold applications where both structural support and therapeutic release are needed.
期刊介绍:
The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.