Pritipragatika Nayak , Surya Kanta Swain , Itishree Jogamaya Das , Sushree Sambita Swain , Bikash Ranjan Jena , Himansu Bhusan Samal
{"title":"局部纳米颗粒治疗皮肤癌:目前的关注和挑战","authors":"Pritipragatika Nayak , Surya Kanta Swain , Itishree Jogamaya Das , Sushree Sambita Swain , Bikash Ranjan Jena , Himansu Bhusan Samal","doi":"10.1016/j.jddst.2025.107566","DOIUrl":null,"url":null,"abstract":"<div><div>Skin cancer (SC), commonly known as melanoma, has become a predominant malignancy among humans. The skin is a widely utilized pathway for administering both local and systemic drugs, presenting the potential for nanoparticle-based delivery. SC treatment varies based on the disease stage. Many techniques, including radiotherapy, Surgery, and chemotherapy, are now being used to diagnose SC. However, the limitation of the current treatment approach is that researchers are searching for an improved delivery system to achieve better outcomes. Various pharmaceutical approaches, from nanotechnology to physical enhancement techniques, are presently being developed to improve medication delivery systems for specific targeted tumors. The topical method of drug delivery is the most well-known strategy for delivering nanoparticles to the dermal layer. The stratum corneum, which forms the uppermost layer, represents a significant barrier to the skin. To overcome these problems, nanotechnology has sparked a growing interest in its application in treating SC by offering efficient drug delivery at lower toxicity levels. Topical delivery of drugs offers effective administration due to their numerous benefits, including avoiding fast-pass hepatic metabolism, reducing systemic side effects, and non-invasiveness. This comprehensive review highlights the latest developments in various nanoparticle technologies for treating skin cancer both systemically and topically, as well as provides a summary of relevant patents and clinical trial outcomes.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107566"},"PeriodicalIF":4.9000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Topical nanoparticles for the treatment of skin cancer: Present concerns and challenges\",\"authors\":\"Pritipragatika Nayak , Surya Kanta Swain , Itishree Jogamaya Das , Sushree Sambita Swain , Bikash Ranjan Jena , Himansu Bhusan Samal\",\"doi\":\"10.1016/j.jddst.2025.107566\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Skin cancer (SC), commonly known as melanoma, has become a predominant malignancy among humans. The skin is a widely utilized pathway for administering both local and systemic drugs, presenting the potential for nanoparticle-based delivery. SC treatment varies based on the disease stage. Many techniques, including radiotherapy, Surgery, and chemotherapy, are now being used to diagnose SC. However, the limitation of the current treatment approach is that researchers are searching for an improved delivery system to achieve better outcomes. Various pharmaceutical approaches, from nanotechnology to physical enhancement techniques, are presently being developed to improve medication delivery systems for specific targeted tumors. The topical method of drug delivery is the most well-known strategy for delivering nanoparticles to the dermal layer. The stratum corneum, which forms the uppermost layer, represents a significant barrier to the skin. To overcome these problems, nanotechnology has sparked a growing interest in its application in treating SC by offering efficient drug delivery at lower toxicity levels. Topical delivery of drugs offers effective administration due to their numerous benefits, including avoiding fast-pass hepatic metabolism, reducing systemic side effects, and non-invasiveness. This comprehensive review highlights the latest developments in various nanoparticle technologies for treating skin cancer both systemically and topically, as well as provides a summary of relevant patents and clinical trial outcomes.</div></div>\",\"PeriodicalId\":15600,\"journal\":{\"name\":\"Journal of Drug Delivery Science and Technology\",\"volume\":\"114 \",\"pages\":\"Article 107566\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug Delivery Science and Technology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1773224725009694\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Delivery Science and Technology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1773224725009694","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Topical nanoparticles for the treatment of skin cancer: Present concerns and challenges
Skin cancer (SC), commonly known as melanoma, has become a predominant malignancy among humans. The skin is a widely utilized pathway for administering both local and systemic drugs, presenting the potential for nanoparticle-based delivery. SC treatment varies based on the disease stage. Many techniques, including radiotherapy, Surgery, and chemotherapy, are now being used to diagnose SC. However, the limitation of the current treatment approach is that researchers are searching for an improved delivery system to achieve better outcomes. Various pharmaceutical approaches, from nanotechnology to physical enhancement techniques, are presently being developed to improve medication delivery systems for specific targeted tumors. The topical method of drug delivery is the most well-known strategy for delivering nanoparticles to the dermal layer. The stratum corneum, which forms the uppermost layer, represents a significant barrier to the skin. To overcome these problems, nanotechnology has sparked a growing interest in its application in treating SC by offering efficient drug delivery at lower toxicity levels. Topical delivery of drugs offers effective administration due to their numerous benefits, including avoiding fast-pass hepatic metabolism, reducing systemic side effects, and non-invasiveness. This comprehensive review highlights the latest developments in various nanoparticle technologies for treating skin cancer both systemically and topically, as well as provides a summary of relevant patents and clinical trial outcomes.
期刊介绍:
The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.