青少年急性消毒药和乙醇中毒：挪威奥斯陆2014-2023年的一项观察性研究

Q1 Environmental Science

Toxicology Reports Pub Date : 2025-09-30 DOI:10.1016/j.toxrep.2025.102134

Ingrid M. Stenbeck , Lüsette A. Subi , Mette Brekke , Odd Martin Vallersnes

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引用次数: 0

摘要

为了跟踪趋势和随时间的变化，我们描述了2014年至2023年挪威奥斯陆青少年的药物服用、临床过程以及娱乐性药物和乙醇中毒的发生率。方法纳入2014-2023年（2018年起）在该市主要急诊初级保健诊所就诊的所有≤ 20岁的娱乐性药物中毒患者，其中也包括单纯的乙醇中毒。资料回顾性地从当地患者记录中收集。据估计，奥斯陆每年每1000名10-20岁居民中就有发病率。结果娱乐性药物中毒1209例，其中女生占51.1% 。吸食大麻的占37.1% %，吸食苯二氮卓类药物的占22.2% %，吸食海洛因的占17.1% %，吸食可卡因的占14.6% %，吸食安非他命的占13.1 %，吸食亚甲二氧基甲基安非他命（MDMA）的占12.2 %。406例（33.6% %）患者同时服用一种以上药物。单纯乙醇中毒1675例，女生59.9 %。在2020年和2021年大流行期间，单纯乙醇中毒发生率暂时下降，同时娱乐性药物中毒发生率上升。其他方面，除2023年娱乐性药物中毒发生率明显上升外，其余年份均保持稳定：2014年娱乐性药物中毒发生率为1.20(95 % CI 0.97-1.50)， 2023年为3.55 (3.16-3.99)；单独乙醇中毒2018年3.94(3.50-4.42)，2023年3.96（3.54-4.42）。在研究初期，女孩的娱乐性药物中毒发生率低于男孩，但从2021年开始上升。结论奥斯陆青少年娱乐性药物中毒以乙醇、大麻、苯二氮卓类药物和海洛因为主。

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Acute recreational drug and ethanol poisoning among adolescents: An observational study from Oslo, Norway 2014–2023

Aims

To keep track on trends and changes over time, we describe drugs taken, clinical course, and incidence of recreational drug and ethanol poisoning among adolescents in Oslo, Norway, from 2014 to 2023.

Methods

We included all patients ≤ 20 years presenting to the city’s main emergency primary care clinic with recreational drug poisoning in 2014–2023, from 2018 also including sole ethanol poisoning. Data were retrospectively collected from local patient records. Incidences were estimated per 1000 inhabitants in Oslo aged 10–20 years per year.

Results

There were 1209 recreational drug poisonings, 51.1 % among girls. Cannabis was taken in 37.1 % of the cases, benzodiazepines in 22.2 %, heroin in 17.1 %, cocaine in 14.6 %, amphetamine in 13.1 %, and methylenedioxymethamphetamine (MDMA) in 12.2 %. More than one drug was taken in 406 (33.6 %) cases. There were 1675 sole ethanol poisonings, 59.9 % among girls. During the pandemic years 2020 and 2021 there was a temporary decrease in the incidence of sole ethanol poisoning, accompanied by an increase in recreational drug poisoning. Otherwise, the incidences were stable, except a marked increase for recreational drugs in 2023: recreational drug poisoning 1.20 (95 % CI 0.97–1.50) in 2014 and 3.55 (3.16–3.99) in 2023; sole ethanol poisoning 3.94 (3.50–4.42) in 2018 and 3.96 (3.54–4.42) in 2023. The incidence of recreational drug poisoning among girls were lower than among boys early in the study period, but higher from 2021.