移动可变形构件法设计新型非周期仿生骨支架

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design Pub Date : 2025-09-24 DOI:10.1016/j.matdes.2025.114815

Hao Wang , Jiongyi Wu , Yuhang Chen , Michael Zhuravkov , Sergei Bosiakov , Youwei Zhang , Mohammed Rafiq Abdul Kadir , Jian Jiang , Yongtao Lyu

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引用次数: 0

摘要

骨支架在骨科中广泛应用于组织修复和再生，但通过多孔支架实现最佳骨生长仍然是一个重大挑战。本研究采用移动可变形构件（MMC）方法设计新型非周期仿生骨支架。四种类型的支架被用来模拟不同的人类骨组织。对它们的平均弹性模量进行了评估，发现它们与相应的骨组织的弹性模量密切匹配。与三周期最小表面（TPMS）结构相比，新型支架具有更高的渗透率-高达3.70 × 10−8 m2，孔隙率为62%。这些支架不仅具有良好的力学性能，而且具有良好的透气性。此外，它们具有良好的可制造性，使其具有实际的制造价值。总的来说，mmc设计的支架具有匹配的力学性能和优异的渗透性，在组织工程应用中有可能减少应力屏蔽，促进骨细胞生长和再生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Design of novel non-periodic biomimetic bone scaffolds using the Moving Morphable Components method

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Design of novel non-periodic biomimetic bone scaffolds using the Moving Morphable Components method

Bone scaffolds are widely used in orthopedics for tissue repair and regeneration, yet achieving optimal bone growth through porous scaffolds remains a significant challenge. In this study, the Moving Morphable Components (MMC) method was employed to design novel non-periodic biomimetic bone scaffolds. Four types of scaffolds were created to mimic different human bone tissues. Their average elastic moduli were evaluated, and found to closely match with those of the corresponding bone tissues. Compared to triply periodic minimal surface (TPMS) structures, the novel scaffolds exhibited significantly higher permeability − up to 3.70 × 10⁻⁸ m² at a porosity of 62 %. These scaffolds demonstrated not only suitable mechanical properties but also enhanced permeability. Furthermore, they showed a good manufacturability, making them practical for fabrication. Overall, the MMC-designed scaffolds present a promising solution with matched mechanical properties and superior permeability, potentially reducing stress shielding and promoting bone cell growth and regeneration in tissue engineering applications.

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来源期刊

Materials & Design Engineering-Mechanical Engineering

CiteScore

14.30

自引率

7.10%

发文量

1028

审稿时长

85 days

期刊介绍： Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.