基于Ni-MOF/MWCNTs的电化学传感器用于药物柠檬酸伊唑唑米的选择性检测

IF 4.1 3区化学 Q1 CHEMISTRY, ANALYTICAL

Journal of Electroanalytical Chemistry Pub Date : 2025-09-26 DOI:10.1016/j.jelechem.2025.119510

Mahmoud Roushani, Zahra Mirzaei Karazan, Ammar Khaled Abdel-Wahid

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引用次数: 0

摘要

设计了一种基于ni -金属有机骨架/多壁碳纳米管（Ni-MOF/MWCNTs）修饰的玻碳电极（GCE）电化学传感器，用于检测柠檬酸Ixazomib （IXM）药物。通过电化学阻抗谱（EIS）、差分脉冲伏安法（DPV）和循环伏安法（CV）对改性电极进行了电化学测试。引入的传感器由于MWCNTs和Ni-MOF的协同作用而表现出优异的电催化反应。所设计的电极线性范围为0.01 ~ 1000 nM， IXM的检出限为0.003 nM。该电化学平台显示出可接受的再现性、重复性和稳定性。结果证明了该传感器在选择性检测IXM方面的潜力。最后，该电化学传感器具有良好的实际应用潜力。从这个意义上说，设计的传感器用于实际样品中的IXM检测，结果可以接受。

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Electrochemical sensor based on Ni-MOF/MWCNTs for the selective detection of drug Ixazomib citrate

An electrochemical sensor was designed based on glassy carbon electrode (GCE) modified with Ni-metal organic framework/multi-walled carbon nanotubes (Ni-MOF/MWCNTs) for the detection of Ixazomib citrate (IXM) drug. Electrochemical tests were carried out on the modified electrode via electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The introduced sensor displayed excellent electrocatalytic response due to synergistic effect of MWCNTs and Ni-MOF. The designed electrode demonstrates wide linear range from 0.01 to 1000 nM, with detection limit (LOD) of 0.003 nM for IXM. This electrochemical platform displayed acceptable reproducibility, repeatability, and stability. The results prove the sensor's potential for the selective detection IXM. Finally, the electrochemical sensor has a good potential for practical applications. In this sense, the designed sensor was used to detect IXM in actual sample with acceptable results.

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来源期刊

Journal of Electroanalytical Chemistry 化学-电化学

CiteScore

7.80

自引率

6.70%

发文量

912

审稿时长

2.4 months

期刊介绍： The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied. Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.