细胞周期蛋白在调节肿瘤免疫微环境中的作用

IF 9.4 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2025-06-04 DOI:10.1016/j.gendis.2025.101706

Qingbo Zhu, Xiaoli Wei, Ziting Qu, Lili Lu, Yiyin Zhang, Hua Wang

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引用次数: 0

摘要

最近的研究表明，细胞周期蛋白除了调节肿瘤细胞的生长外，还可以调节肿瘤免疫微环境（TIME）中的免疫细胞和因子，从而起到调节肿瘤免疫的作用。本文就细胞周期调控蛋白在TIME调控中的相关机制作一综述。开发针对相关治疗靶点的有效药物可能是下一代抗肿瘤免疫治疗的研究热点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The roles of cell cycle proteins in regulating the tumor immune microenvironment

Recent studies have shown that in addition to regulating the growth of tumor cells, cell cycle proteins can also regulate immune cells and factors in the tumor immune microenvironment (TIME), thus playing a role in regulating tumor immunity. This review summarizes the relevant mechanisms of cell cycle regulatory proteins in TIME regulation. The development of effective drugs against relevant therapeutic targets may be a hot research topic for the next generation of antitumor immunotherapy.

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.