{"title":"为动物生产商提供了一种优化且经济的合成dl -氯前列醇钠的工艺","authors":"Nagarjuna Reddy Guttikonda , Muvvala Venkatanarayana , Sharath Babu Haridasyam , Battula Sreenivasa Rao","doi":"10.1016/j.rechem.2025.102748","DOIUrl":null,"url":null,"abstract":"<div><div>An improved and scalable process for the synthesis of DL-cloprostenol sodium salt has been developed. The route furnishes a 1:1 mixture of diastereomers in nine steps, achieving an overall yield of 44 % from (−)-Corey lactone diol. The synthetic strategy avoids repeated purification steps and employs a single column purification, thereby reducing solvent consumption and minimizing solvent waste. Owing to its efficiency and operational simplicity, the process is suitable for large-scale production and offers advantages over previously reported methods.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"18 ","pages":"Article 102748"},"PeriodicalIF":4.2000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An optimized and affordable process for the synthesis of DL-Cloprostenol sodium for animal producers\",\"authors\":\"Nagarjuna Reddy Guttikonda , Muvvala Venkatanarayana , Sharath Babu Haridasyam , Battula Sreenivasa Rao\",\"doi\":\"10.1016/j.rechem.2025.102748\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>An improved and scalable process for the synthesis of DL-cloprostenol sodium salt has been developed. The route furnishes a 1:1 mixture of diastereomers in nine steps, achieving an overall yield of 44 % from (−)-Corey lactone diol. The synthetic strategy avoids repeated purification steps and employs a single column purification, thereby reducing solvent consumption and minimizing solvent waste. Owing to its efficiency and operational simplicity, the process is suitable for large-scale production and offers advantages over previously reported methods.</div></div>\",\"PeriodicalId\":420,\"journal\":{\"name\":\"Results in Chemistry\",\"volume\":\"18 \",\"pages\":\"Article 102748\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Results in Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211715625007313\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211715625007313","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
An optimized and affordable process for the synthesis of DL-Cloprostenol sodium for animal producers
An improved and scalable process for the synthesis of DL-cloprostenol sodium salt has been developed. The route furnishes a 1:1 mixture of diastereomers in nine steps, achieving an overall yield of 44 % from (−)-Corey lactone diol. The synthetic strategy avoids repeated purification steps and employs a single column purification, thereby reducing solvent consumption and minimizing solvent waste. Owing to its efficiency and operational simplicity, the process is suitable for large-scale production and offers advantages over previously reported methods.
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