基于锌、铈- mof纳米复合材料的双模荧光/比色传感器对异碳磷的灵敏检测

IF 6 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2025-10-03 DOI:10.1016/j.aca.2025.344739

Yimeng Li , Jiayao Wang , Yi Ran , Yiwei Liu , Xiaopeng Hu

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引用次数: 0

摘要

研究了一种双模荧光/比色法适体传感器，用于对具有重大公共健康风险的有机磷农药异碳磷进行灵敏检测。该传感器采用Zn、Ce-MOF纳米复合材料，集磁分离和信号放大于一体。这种集成的生物传感策略为环境安全保证和食品质量控制应用提供了一种有前途的工具。结果该传感器的Zn，Ce-MOF纳米酶作为3,3 ',5,5 ' -四甲基联苯胺（TMB）的载体和氧化酶模拟物，促进了TMB的无酶氧化。双读出系统可通过独立通道进行自我验证检测（荧光LOD: 0.06 ng mL-1；比色LOD: 0.09 ng mL-1），具有稳定的性能、高干扰选择性和重复性。在加标农业样品中进行实际验证，回收率为97.7-113.6%，证实了该平台适用于现场部署的农药监测。意义：利用自组装的TMB/Au/Zn，Ce-MOF探针，研制了一种用于一步磁分离双模检测的荧光/视觉适配体传感器。这种集成的生物传感策略提高了检测效率和准确性，为多模态生物传感器提供了一种通用策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dual-mode fluorescence/colorimetric aptasensor based on Zn,Ce-MOF nanocomposite for sensitive detection of isocarbophos

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Dual-mode fluorescence/colorimetric aptasensor based on Zn,Ce-MOF nanocomposite for sensitive detection of isocarbophos

Background

A dual-mode fluorescence/colorimetric aptasensor was developed for the sensitive detection of isocarbophos, an organophosphorus pesticide posing significant public health risks. Using Zn,Ce-MOF nanocomposites, this sensor integrated magnetic separation and signal amplification. This integrated biosensing strategy offers a promising tool for environmental safety assurance and food quality control applications.

Results

The Zn,Ce-MOF nanozyme of this sensor serves as both a carrier of 3,3′,5,5′-tetramethylbenzidine (TMB) and oxidase mimic, facilitating enzyme-free TMB oxidation. The dual-readout system enables self-validating detection through independent channels (fluorescence LOD: 0.06 ng mL⁻¹; colorimetric LOD: 0.09 ng mL⁻¹), with robust performance, high interferent selectivity, and reproducibility. Practical validation in spiked agricultural samples yielded recovery rates of 97.7–113.6 %, confirming the platform's suitability for field-deployable pesticide monitoring.

Significance

This work developed a fluorescence/visual aptasensor with self-assembled TMB/Au/Zn,Ce-MOF probes for one-step magnetic separation dual-mode detection. This integrated biosensing strategy improves detection efficiency and accuracy, offering a general strategy for multimodal biosensors.

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.