光化学烯丙胺的无金属氢氨基化

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-10-04 DOI:10.1002/adsc.70148

Mariusz Zalewski, Sebastian Stecko

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引用次数: 0

摘要

本文报道了一种在无金属和温和条件下烯丙胺氢氨基化的光氧化还原催化方案。所提出的方法利用易于获得的4 -羧基氨基汉奇酯作为方便的底物，在可见光介导的SET过程中传递氨基甲酰自由基。它们添加到各种烯丙胺的效率很高，并且具有高水平的区域选择性和化学选择性，以提供相应的γ -氨基酸酰胺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photochemical Metal‐Free Hydrocarbamoylation of Allylamines

Herein, a photoredox‐catalyzed protocol for allylamine hydrocarbamoylation under metal‐free and mild conditions is reported. The proposed method utilizes readily accessible 4‐carboxyamido Hantzsch esters as convenient substrates that deliver carbamoyl radicals upon a visible light‐mediated SET process. Their addition to various allylamines proceeds with good‐to‐excellent efficiency and with high levels of regio‐ and chemoselectivity to provide the corresponding γ‐amino acid amides.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.