特应性皮炎的预测性生物标志物。

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Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pub Date : 2025-10-01 DOI:10.1111/pai.70215

Jessica W Hui-Beckman, Elena Goleva, Donald Y M Leung

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引用次数: 0

摘要

发现特应性皮炎（AD）的早期临床前生物标志物是预防AD发展和早期引入治疗措施以降低AD严重程度的重要研究领域。在世界范围内进行的出生队列研究已经深入了解了皮肤屏障成分，如脂质和蛋白质、细胞因子免疫标记物和AD临床诊断前存在的微生物组改变。本文综述了存在AD风险的儿童皮肤屏障结构和早期生命生物标志物。

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Predictive biomarkers for atopic dermatitis.

The discovery of early-life preclinical biomarkers for atopic dermatitis (AD) is an important area of research to prevent AD development and introduce treatment measures early to reduce AD severity. Birth cohort studies performed worldwide have given insights into skin barrier components, such as lipids and proteins, cytokine immunologic markers, and microbiome alterations that are present prior to the clinical diagnosis of AD. This article reviews the structure of the skin barrier and the early-life biomarkers that are present in children at risk for AD.

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Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

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