{"title":"氢氧化钙、三联抗生素糊剂和氢氧化钙加2%氯己定作为根管治疗期间减少预约间疼痛的管内药物的比较评价：一项体内研究。","authors":"Itika Jain, Shyam Agrawal, Rachit Mathur, Shaista Gazal, Akshada Mungee, Babra Khan","doi":"10.5005/jp-journals-10005-2981","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims and background: </strong>Root canal infections are primarily caused by microorganisms present within the pulp tissue and dentinal tubules. Intracanal medicaments are used to eliminate or suppress these microorganisms, reducing the risk of reinfection and promoting healing. The aim of this study was to evaluate the efficacy of calcium hydroxide [Ca(OH)<sub>2</sub>], triple antibiotic paste (TAP), and Ca(OH)<sub>2</sub> with 2% chlorhexidine (CHX) as intracanal medicaments in reducing interappointment pain.</p><p><strong>Materials and methods: </strong>Ninety-two patients were randomly selected for this study, fitting the inclusion criteria. They were divided into four groups: group I (control group), group II [Ca(OH)<sub>2</sub>], group III (TAP), and group IV [Ca(OH)<sub>2</sub> with 2% CHX (Ca(OH)<sub>2</sub> + CHX)]. Intracanal medicament was placed following biomechanical preparation. The pain was measured using visual analog scale (VAS), and the scores were recorded at 0, 24, 48, and 72 hours. Data analysis was done using Statistical Package for Social Sciences (SPSS) software, with a <i>p</i>-value < 0.05 considered significant. The Chi-squared test and the <i>t</i>-test were used to compare pain scores between different groups and at different time periods of the study.</p><p><strong>Results: </strong>The preoperative mean pain scores were similar for all the groups, with no statistical difference between them. All treatment groups (groups II, III, and IV) had lower pain scores compared to the control group (group I) across all time points. Additionally, group III (TAP) consistently had the lowest pain scores among all groups at each time point, indicating potentially superior pain reduction efficacy compared to the other treatments.</p><p><strong>Conclusion: </strong>Within the limitations of this study, TAP and [Ca(OH)<sub>2</sub> + CHX] are more effective at reducing pain compared to using Ca(OH)<sub>2</sub> alone, with TAP providing the most significant benefit.</p><p><strong>Clinical significance: </strong>This research provides insightful information for the selection and use of intracanal medicaments in endodontic therapy, which can guide clinical decisions and enhance patient care.</p><p><strong>How to cite this article: </strong>Jain I, Agrawal S, Mathur R, <i>et al.</i> Comparative Evaluation of Calcium Hydroxide, Triple Antibiotic Paste, and Calcium Hydroxide with 2% Chlorhexidine as Intracanal Medicaments in Reducing Interappointment Pain during Endodontic Treatment: An <i>In Vivo</i> Study. Int J Clin Pediatr Dent 2025;18(6):628-631.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 6","pages":"753-758"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486467/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparative Evaluation of Calcium Hydroxide, Triple Antibiotic Paste, and Calcium Hydroxide with 2% Chlorhexidine as Intracanal Medicaments in Reducing Interappointment Pain during Endodontic Treatment: An <i>In Vivo</i> Study.\",\"authors\":\"Itika Jain, Shyam Agrawal, Rachit Mathur, Shaista Gazal, Akshada Mungee, Babra Khan\",\"doi\":\"10.5005/jp-journals-10005-2981\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims and background: </strong>Root canal infections are primarily caused by microorganisms present within the pulp tissue and dentinal tubules. Intracanal medicaments are used to eliminate or suppress these microorganisms, reducing the risk of reinfection and promoting healing. The aim of this study was to evaluate the efficacy of calcium hydroxide [Ca(OH)<sub>2</sub>], triple antibiotic paste (TAP), and Ca(OH)<sub>2</sub> with 2% chlorhexidine (CHX) as intracanal medicaments in reducing interappointment pain.</p><p><strong>Materials and methods: </strong>Ninety-two patients were randomly selected for this study, fitting the inclusion criteria. They were divided into four groups: group I (control group), group II [Ca(OH)<sub>2</sub>], group III (TAP), and group IV [Ca(OH)<sub>2</sub> with 2% CHX (Ca(OH)<sub>2</sub> + CHX)]. Intracanal medicament was placed following biomechanical preparation. The pain was measured using visual analog scale (VAS), and the scores were recorded at 0, 24, 48, and 72 hours. Data analysis was done using Statistical Package for Social Sciences (SPSS) software, with a <i>p</i>-value < 0.05 considered significant. The Chi-squared test and the <i>t</i>-test were used to compare pain scores between different groups and at different time periods of the study.</p><p><strong>Results: </strong>The preoperative mean pain scores were similar for all the groups, with no statistical difference between them. All treatment groups (groups II, III, and IV) had lower pain scores compared to the control group (group I) across all time points. Additionally, group III (TAP) consistently had the lowest pain scores among all groups at each time point, indicating potentially superior pain reduction efficacy compared to the other treatments.</p><p><strong>Conclusion: </strong>Within the limitations of this study, TAP and [Ca(OH)<sub>2</sub> + CHX] are more effective at reducing pain compared to using Ca(OH)<sub>2</sub> alone, with TAP providing the most significant benefit.</p><p><strong>Clinical significance: </strong>This research provides insightful information for the selection and use of intracanal medicaments in endodontic therapy, which can guide clinical decisions and enhance patient care.</p><p><strong>How to cite this article: </strong>Jain I, Agrawal S, Mathur R, <i>et al.</i> Comparative Evaluation of Calcium Hydroxide, Triple Antibiotic Paste, and Calcium Hydroxide with 2% Chlorhexidine as Intracanal Medicaments in Reducing Interappointment Pain during Endodontic Treatment: An <i>In Vivo</i> Study. Int J Clin Pediatr Dent 2025;18(6):628-631.</p>\",\"PeriodicalId\":36045,\"journal\":{\"name\":\"International Journal of Clinical Pediatric Dentistry\",\"volume\":\"18 6\",\"pages\":\"753-758\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486467/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical Pediatric Dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5005/jp-journals-10005-2981\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Pediatric Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5005/jp-journals-10005-2981","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 0
摘要
目的和背景：根管感染主要是由存在于牙髓组织和牙本质小管中的微生物引起的。使用肛管内药物来消除或抑制这些微生物，减少再感染的风险并促进愈合。本研究的目的是评估氢氧化钙[Ca(OH)2]、三联抗生素糊剂（TAP）和Ca(OH)2加2%氯己定（CHX）作为肛管内药物减轻预约间疼痛的疗效。材料与方法：本研究随机选取92例符合纳入标准的患者。将其分为4组：I组（对照组）、II组[Ca(OH)2]、III组（TAP）和IV组[Ca(OH)2 + 2% CHX]。生物力学准备完成后，给予管内药物治疗。采用视觉模拟评分法（VAS）测量疼痛，分别于0、24、48、72小时进行评分。数据分析采用SPSS （Statistical Package for Social Sciences）软件，p值< 0.05为显著性。采用卡方检验和t检验比较不同组间和研究不同时间段的疼痛评分。结果：两组患者术前平均疼痛评分相近，差异无统计学意义。所有治疗组（II组、III组和IV组）在所有时间点的疼痛评分均低于对照组（I组）。此外，在所有组中，在每个时间点，III组（TAP）的疼痛评分始终最低，表明与其他治疗相比，可能具有更好的疼痛减轻效果。结论：在本研究的限制范围内，与单独使用Ca(OH)2相比，TAP和[Ca(OH)2 + CHX]在减轻疼痛方面更有效，其中TAP提供了最显著的益处。临床意义：本研究为根管治疗中管内药物的选择和使用提供了有见地的信息，可以指导临床决策，加强患者护理。如何引用本文：Jain I， Agrawal S， Mathur R等人。氢氧化钙、三联抗生素糊剂和氢氧化钙加2%氯己定作为根管治疗期间减少预约间疼痛的管内药物的比较评价：一项体内研究。中华临床儿科杂志，2015;18(6):628-631。
Comparative Evaluation of Calcium Hydroxide, Triple Antibiotic Paste, and Calcium Hydroxide with 2% Chlorhexidine as Intracanal Medicaments in Reducing Interappointment Pain during Endodontic Treatment: An In Vivo Study.
Aims and background: Root canal infections are primarily caused by microorganisms present within the pulp tissue and dentinal tubules. Intracanal medicaments are used to eliminate or suppress these microorganisms, reducing the risk of reinfection and promoting healing. The aim of this study was to evaluate the efficacy of calcium hydroxide [Ca(OH)2], triple antibiotic paste (TAP), and Ca(OH)2 with 2% chlorhexidine (CHX) as intracanal medicaments in reducing interappointment pain.
Materials and methods: Ninety-two patients were randomly selected for this study, fitting the inclusion criteria. They were divided into four groups: group I (control group), group II [Ca(OH)2], group III (TAP), and group IV [Ca(OH)2 with 2% CHX (Ca(OH)2 + CHX)]. Intracanal medicament was placed following biomechanical preparation. The pain was measured using visual analog scale (VAS), and the scores were recorded at 0, 24, 48, and 72 hours. Data analysis was done using Statistical Package for Social Sciences (SPSS) software, with a p-value < 0.05 considered significant. The Chi-squared test and the t-test were used to compare pain scores between different groups and at different time periods of the study.
Results: The preoperative mean pain scores were similar for all the groups, with no statistical difference between them. All treatment groups (groups II, III, and IV) had lower pain scores compared to the control group (group I) across all time points. Additionally, group III (TAP) consistently had the lowest pain scores among all groups at each time point, indicating potentially superior pain reduction efficacy compared to the other treatments.
Conclusion: Within the limitations of this study, TAP and [Ca(OH)2 + CHX] are more effective at reducing pain compared to using Ca(OH)2 alone, with TAP providing the most significant benefit.
Clinical significance: This research provides insightful information for the selection and use of intracanal medicaments in endodontic therapy, which can guide clinical decisions and enhance patient care.
How to cite this article: Jain I, Agrawal S, Mathur R, et al. Comparative Evaluation of Calcium Hydroxide, Triple Antibiotic Paste, and Calcium Hydroxide with 2% Chlorhexidine as Intracanal Medicaments in Reducing Interappointment Pain during Endodontic Treatment: An In Vivo Study. Int J Clin Pediatr Dent 2025;18(6):628-631.
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