靶向肿瘤相关神经增强癌症免疫治疗。

IF 15 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-10-01 DOI:10.1016/j.neuron.2025.09.005

Canhui Cao

引用次数: 0

摘要

肿瘤相关神经积极塑造肿瘤免疫。在最近一期的《自然》杂志上，Baruch等人1表明，癌症诱导的神经损伤会导致T细胞衰竭并破坏PD-1阻断。靶向这种神经免疫串扰是一种很有前途的增强癌症免疫治疗的策略。

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Targeting tumor-associated nerves enhances cancer immunotherapy.

Tumor-associated nerves actively shape tumor immunity. In a recent issue of Nature, Baruch et al.¹ show that cancer-induced nerve injury drives T cell exhaustion and undermines PD-1 blockade. Targeting this neuro-immune crosstalk is a promising strategy to enhance cancer immunotherapy.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.