表观遗传学在癌症中的作用:从途径到临床。

IF 1 Q4 PRIMARY HEALTH CARE
Abdulraheem A Almalki
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引用次数: 0

摘要

表观遗传变化是遗传的,但可修复的基因DNA修饰,影响基因表达,而不考虑潜在的序列。表观遗传异常与包括癌症在内的多种人类疾病有关。恶性肿瘤可由异常的表观遗传变化引起,这些变化错误地激活了致癌基因。表观遗传标记是有吸引力的治疗靶点,因为它们是可逆的,易受外源性变化的影响。在过去几年中,针对表观遗传调控的治疗方法取得了重大进展,几种药物正在评估中。本文综述了目前正在进行临床试验的表观遗传药物。本文还讨论了使用它们治疗癌症的利弊以及表观遗传学在癌症诊断中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of epigenetics in cancer: From pathways to the clinic.

The role of epigenetics in cancer: From pathways to the clinic.

The role of epigenetics in cancer: From pathways to the clinic.

The role of epigenetics in cancer: From pathways to the clinic.

Epigenetic changes are inherited but repairable genetic DNA modifications that affect gene expression regardless of the underlying sequence. Epigenetic abnormalities have been associated with a wide range of human diseases, including cancer. Malignancy can be caused by abnormal epigenetic changes that incorrectly activate oncogenes. Epigenetic marks are appealing therapeutic targets because they are reversible and susceptible to exogenous changes. Significant progress has been made in developing treatments that target epigenetic regulation in the past few years, with several pharmaceuticals being evaluated. this review describes the epigenetic drugs currently undergoing clinical trials. It also discusses the pros and cons of using them to treat cancer and the role of epigenetics in cancer diagnosis.

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