Rose Mary Jacob Vatakencherry, Susan John, Veena Shenoy, L Saraswathy
{"title":"喀拉拉邦中部一家教学医院产前妇女同种异体抗体的流行","authors":"Rose Mary Jacob Vatakencherry, Susan John, Veena Shenoy, L Saraswathy","doi":"10.4103/jfmpc.jfmpc_407_25","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Rh immunoprophylaxis has helped to decrease the prevalence of Rh D associated Haemolytic disease of New-born and Foetus. 50 different RBC antigens have been reported to be associated with HDFN. The current incidence of alloimmunization due to non-RhD antibodies in Western countries is 0.28-0.33%. A study on 707 neonates showed antigen-positivity and evidence of HDFN in 37%, with the most severe with DAT-positive anti-Rh antibodies, C, D, e, E. Early detection, monitoring, and planned interventions would help to prevent severe HDFN.</p><p><strong>Materials and methods: </strong>The Study included 370 pregnant women attending the antenatal clinic of our hospital and excluded those with a history of transfusion, haemolytic disease, intrauterine bleeding or intrauterine death. Irregular antibodies were checked by the Indirect Coombs Test (ICT) using ID Diacell I-II-III, Diamed, Switzerland. Specific antibody identification was performed using ID Diapanel, Diamed, Switzerland.</p><p><strong>Statistical analysis: </strong>Statistical analysis was done using IBM SPSS Statistics 20.0. Pearson's Chi-square test was applied. Odds ratio and their 95% CI were calculated.</p><p><strong>Results: </strong>Red cell antibody screening was positive in 3.5% (13). Antibodies identified as anti-D (30.8%), anti-c (15.4%), anti-C + D (15.4%), anti-K (15.4%), anti-Le b + Jka (7.7%), anti-E (7.7%), and anti-c + Jka (7.7%).</p><p><strong>Conclusion: </strong>The maternal alloimmunization prevalence was 3.5%. The potential for severe HDFN associated with antibodies such as anti-K, anti-E, and anti-c necessitates vigilant monitoring at the primary care level.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 8","pages":"3538-3541"},"PeriodicalIF":1.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488159/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence of alloantibodies among antenatal women attending a teaching hospital in central Kerala.\",\"authors\":\"Rose Mary Jacob Vatakencherry, Susan John, Veena Shenoy, L Saraswathy\",\"doi\":\"10.4103/jfmpc.jfmpc_407_25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Rh immunoprophylaxis has helped to decrease the prevalence of Rh D associated Haemolytic disease of New-born and Foetus. 50 different RBC antigens have been reported to be associated with HDFN. The current incidence of alloimmunization due to non-RhD antibodies in Western countries is 0.28-0.33%. A study on 707 neonates showed antigen-positivity and evidence of HDFN in 37%, with the most severe with DAT-positive anti-Rh antibodies, C, D, e, E. Early detection, monitoring, and planned interventions would help to prevent severe HDFN.</p><p><strong>Materials and methods: </strong>The Study included 370 pregnant women attending the antenatal clinic of our hospital and excluded those with a history of transfusion, haemolytic disease, intrauterine bleeding or intrauterine death. Irregular antibodies were checked by the Indirect Coombs Test (ICT) using ID Diacell I-II-III, Diamed, Switzerland. Specific antibody identification was performed using ID Diapanel, Diamed, Switzerland.</p><p><strong>Statistical analysis: </strong>Statistical analysis was done using IBM SPSS Statistics 20.0. Pearson's Chi-square test was applied. Odds ratio and their 95% CI were calculated.</p><p><strong>Results: </strong>Red cell antibody screening was positive in 3.5% (13). Antibodies identified as anti-D (30.8%), anti-c (15.4%), anti-C + D (15.4%), anti-K (15.4%), anti-Le b + Jka (7.7%), anti-E (7.7%), and anti-c + Jka (7.7%).</p><p><strong>Conclusion: </strong>The maternal alloimmunization prevalence was 3.5%. The potential for severe HDFN associated with antibodies such as anti-K, anti-E, and anti-c necessitates vigilant monitoring at the primary care level.</p>\",\"PeriodicalId\":15856,\"journal\":{\"name\":\"Journal of Family Medicine and Primary Care\",\"volume\":\"14 8\",\"pages\":\"3538-3541\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488159/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Family Medicine and Primary Care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jfmpc.jfmpc_407_25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PRIMARY HEALTH CARE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Family Medicine and Primary Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jfmpc.jfmpc_407_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/24 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PRIMARY HEALTH CARE","Score":null,"Total":0}
Prevalence of alloantibodies among antenatal women attending a teaching hospital in central Kerala.
Introduction: Rh immunoprophylaxis has helped to decrease the prevalence of Rh D associated Haemolytic disease of New-born and Foetus. 50 different RBC antigens have been reported to be associated with HDFN. The current incidence of alloimmunization due to non-RhD antibodies in Western countries is 0.28-0.33%. A study on 707 neonates showed antigen-positivity and evidence of HDFN in 37%, with the most severe with DAT-positive anti-Rh antibodies, C, D, e, E. Early detection, monitoring, and planned interventions would help to prevent severe HDFN.
Materials and methods: The Study included 370 pregnant women attending the antenatal clinic of our hospital and excluded those with a history of transfusion, haemolytic disease, intrauterine bleeding or intrauterine death. Irregular antibodies were checked by the Indirect Coombs Test (ICT) using ID Diacell I-II-III, Diamed, Switzerland. Specific antibody identification was performed using ID Diapanel, Diamed, Switzerland.
Statistical analysis: Statistical analysis was done using IBM SPSS Statistics 20.0. Pearson's Chi-square test was applied. Odds ratio and their 95% CI were calculated.
Results: Red cell antibody screening was positive in 3.5% (13). Antibodies identified as anti-D (30.8%), anti-c (15.4%), anti-C + D (15.4%), anti-K (15.4%), anti-Le b + Jka (7.7%), anti-E (7.7%), and anti-c + Jka (7.7%).
Conclusion: The maternal alloimmunization prevalence was 3.5%. The potential for severe HDFN associated with antibodies such as anti-K, anti-E, and anti-c necessitates vigilant monitoring at the primary care level.