公开报道的结果对患者选择造血细胞移植的影响。

IF 4.6 3区 医学 Q1 ONCOLOGY
Christopher Strouse, Mark Juckett, Brent R Logan, Noel Estrada-Merly, Andrew Peterson, Jaime M Preussler, Tony H Truong, Jesse D Troy, Nandita Khera, William A Wood, Hemalatha G Rangarajan, Luke P Akard, Neel S Bhatt, Akshay Sharma, J Douglas Rizzo, Wael Saber
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引用次数: 0

摘要

目的:卫生保健结果的公开报告可能产生意想不到的影响,如患者选择中不适当的风险规避。方法:每年的中心特异性生存分析对美国所有造血细胞移植(HCT)中心高于、低于或在中心特异性预测结果范围内的观察结果给予+1、-1或0分。对于每个指标年(2012-2016),将前2年得分为0分后得分为-1的中心与同期预测结果为0分的中心进行比较。比较新低于预期的中心(nbc)和对照组在指标年之前和之后3年患者群体特征的变化。根据基线患者群体特征和中心容积调整的多变量模型。结果:在8个关键患者群体特征上,与对照组相比,在患者选择行为上没有发现差异。对于统计建模(预测)的1年总生存率(OS),反映了中心患者群体风险的整体测量,我们观察到变化没有统计学上的显著差异(-0.23% [95% CI, -1.4至0.9];P = 0.70)。nbc组和对照组观察到的OS分别增加0.9%和4.5%,变化无统计学差异。结论:获得-1分的中心没有观察到明显偏离HCT领域的患者选择趋势。这些发现表明,在美国,HCT结果的公开报告不会导致对高危患者HCT的意外偏见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Publicly Reported Outcomes on Patient Selection for Hematopoietic Cell Transplantation.

Purpose: Public reporting of health care outcomes can have unintended effects such as inappropriate risk aversion in patient selection.

Methods: The center-specific survival analysis annually assigns all hematopoietic cell transplantation (HCT) centers in the United States a +1, -1, or 0 score for observed outcomes that are above, below, or within a center-specific predicted range of outcome. For each index year (2012-2016), centers receiving a -1 score after 0 scores in the preceding 2 years were compared with contemporaneous centers with as-predicted outcomes (0 score). Changes in the patient population characteristics in the 3 years before versus the 3 years after the index years were compared between the newly below-expected centers (NBCs) and the controls. A multivariate model adjusted for baseline patient population characteristics and center volume.

Results: No differences in patient selection behavior were identified when comparing the NBCs with the controls across eight key patient population characteristics. For the statistically modeled (predicted) 1-year overall survival (OS), reflecting a holistic measure of centers' patient population risk, we observed no statistically significant difference in change (-0.23% [95% CI, -1.4 to 0.9]; P = .70). The observed OS increased in both NBCs and controls by 0.9% and 4.5%, respectively, without statistically significant difference in change.

Conclusion: Centers receiving a -1 score were not observed to deviate significantly from patient selection trends in the HCT field. These findings suggest that public reporting of HCT outcomes in the United States does not result in unintended bias against HCT for high-risk patients.

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来源期刊
CiteScore
6.40
自引率
7.50%
发文量
518
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