利用纳米技术改善药物通过血脑屏障的输送,增强神经修复。

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Miaomiao Xu, Heng Wang, Chengchen Wang, Chu Wang, Shenghao Hu, Lixing Weng
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引用次数: 0

摘要

血脑屏障(BBB)是血液和大脑之间的主要界面,维持对中枢神经系统(CNS)正常运作至关重要的微妙平衡和体内平衡。然而,血脑屏障的选择性通透性给药物递送带来了重大挑战,阻碍了中枢神经系统相关疾病的治疗。近年来,技术的进步已经彻底改变了通过血脑屏障给药的方法,但很少有纳米材料在临床试验中取得成功。在这篇综述中,我们首先研究血脑屏障的结构和功能,然后分析药物如何穿透血脑屏障的机制。然后,我们将重点放在利用纳米材料促进BBB交叉的策略上,并根据它们的成分对这些材料进行分类。此外,我们特别强调了纳米材料用于治疗各种中枢神经系统疾病的纳米药物的最新进展,并总结了已经在神经修复临床试验中测试的纳米材料。最后,对该领域的未来发展方向进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Harnessing nanotechnology for improved drug delivery across the blood-brain barrier and enhanced neural repair

Harnessing nanotechnology for improved drug delivery across the blood-brain barrier and enhanced neural repair
The blood–brain barrier (BBB) serves as the primary interface between the bloodstream and the brain, maintaining the delicate balance and homeostasis crucial for the proper functioning of the central nervous system (CNS). However, the BBB’s selective permeability poses significant challenges for drug delivery, hindering the treatment of CNS-related diseases. In recent years, advancements in technology have revolutionized approaches to drug delivery across the BBB, yet few nanomaterials have achieved success in clinical trials. In this review, we first examine the structure and function of the BBB, followed by an analysis of the mechanisms by how drugs can penetrate it. We then focus on strategies that leverage nanomaterials to facilitate BBB crossing, categorizing these materials based on their compositions. Additionally, we specifically highlight recent advances in the development of nanomedicines from nanomaterials for the treatment of various CNS diseases and summarize nanomaterials that have been tested in clinical trials for nerve repair. Finally, we provide a perspective on future directions in this field.
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来源期刊
CiteScore
10.70
自引率
8.60%
发文量
951
审稿时长
72 days
期刊介绍: The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
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