评估改良的5项衰弱指数作为膀胱癌根治性膀胱切除术后长期生存和围手术期预后的预后指标。

IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Ubeyd Sungur, Nahide Kerim Özfiliz, Mithat Ekşi, Taner Kargı, Serdar Karadağ, Alper Bitkin
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引用次数: 0

摘要

背景与目的:本研究探讨膀胱癌根治性膀胱切除术患者术前改良5项衰弱评分(mFI-5)与患者长期生存及术后30天并发症的关系。方法:对2012-2023年间行根治性膀胱切除术的患者进行分析,根据mFI-5评分分为低危(≤1)和高危(≥2)两组。比较两组的总生存期(OS)、肿瘤特异性生存期(CSS)和术后30天并发症。此外,采用Cox比例风险回归分析检验mFI-5评分对OS和CSS的影响。结果:本研究纳入288例患者,手术时平均年龄63.8±9.1岁。mFI-5评分低的患者占77.4% (n = 223),而mFI-5评分高的患者占22.6% (n = 65)。大多数患者为晚期疾病(pT3-pT4占53.8% (n = 155))。mFI-5评分高的患者的OS和CSS明显差于mFI-5评分低的患者(p = 0.002和p = 0.007)。虽然mFI-5评分高组30天死亡率显著高于对照组(p = 0.002),但总并发症发生率差异无统计学意义(p = 0.120)。在多变量Cox比例风险分析中,mFI-5评分被确定为OS和CSS的独立预测因子(分别为p = 0.001和p = 0.003)。结论:基于术前表现,mFI-5评分可以为膀胱癌患者根治性膀胱切除术后的生存提供有价值的预后信息。它是长期生存的独立预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing the use of modified 5-item frailty index as a prognostic marker of long-term survival and perioperative outcomes after radical cystectomy for bladder cancer.

Background and aim: This study investigated the relationship between preoperative Modified 5-item Frailty Score (mFI-5) and long-term survival as well as 30-day postoperative complications in patients who underwent radical cystectomy for bladder cancer.

Methods: Patients who underwent radical cystectomy between 2012-2023 were analyzed and divided into two groups based on their mFI-5 scores: low-risk (≤ 1) and high-risk (≥ 2). Overall survival (OS), cancer-specific survival (CSS), and 30-day postoperative complications were compared between these groups. Additionally, Cox proportional hazards regression analysis was used to examine the impact of the mFI-5 score on OS and CSS.

Results: Our study included 288 patients with an average age of 63.8 ± 9.1 years at the time of surgery. Patients with a low mFI-5 score comprised 77.4% (n = 223) of the cohort, while 22.6% (n = 65) had a high mFI-5 score. The majority of patients had advanced-stage disease (pT3-pT4 for 53.8% (n = 155)). Patients with a high mFI-5 score demonstrated significantly worse OS and CSS compared to those with a low mFI-5 score (p = 0.002 and p = 0.007, respectively). Although 30-day mortality rates were significantly higher in the high mFI-5 score group (p = 0.002), the difference in overall complication rates was not statistically significant (p = 0.120). In multivariate Cox proportional hazards analysis, the mFI-5 score was identified as an independent predictor for both OS and CSS (p = 0.001 and p = 0.003, respectively).

Conclusion: mFI-5 score can provide valuable prognostic information regarding survival after radical cystectomy in bladder cancer patients, based on preoperative findings. It is an independent predictor of long-term survival.

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来源期刊
Irish Journal of Medical Science
Irish Journal of Medical Science 医学-医学:内科
CiteScore
3.70
自引率
4.80%
发文量
357
审稿时长
4-8 weeks
期刊介绍: The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.
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