Mohamed K A Awad, Ahmed E Ali, Muhammad S Mazroua, Karim Ali, Radwa K Awad, Toqa R Mohamed, Mohamed Abdelmaksoud, Mahmoud A Hashim, Redi Nikollari, Panos N Vardas, Hussein Abu-Daya
{"title":"心脏手术围手术期中性粒细胞与淋巴细胞比值的最新证据:对术后房颤的预后和诊断价值的双重分析。","authors":"Mohamed K A Awad, Ahmed E Ali, Muhammad S Mazroua, Karim Ali, Radwa K Awad, Toqa R Mohamed, Mohamed Abdelmaksoud, Mahmoud A Hashim, Redi Nikollari, Panos N Vardas, Hussein Abu-Daya","doi":"10.1016/j.hrthm.2025.09.036","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Post-operative atrial fibrillation (POAF) is a frequent complication after cardiac surgery, increasing morbidity. The neutrophil/lymphocyte ratio (NLR), a simple marker of systemic inflammation, has been studied as a predictor.</p><p><strong>Objective: </strong>Assess association between NLR and new-onset POAF.</p><p><strong>Methods: </strong>We systematically searched PubMed, Scopus, Web of Science, and Embase through June 2025 for studies reporting preoperative or postoperative NLR and incidence of POAF in adult cardiac surgery patients. Diagnostic test accuracy (DTA) was assessed to evaluate the predictive performance of preoperative NLR for postoperative atrial fibrillation, using pooled sensitivity, specificity, and likelihood ratios. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity.</p><p><strong>Results: </strong>Thirty-two studies (20,056 patients) were included. In 27 studies excluding preoperative AF (13,630 patients), POAF was associated with significantly higher preoperative NLR (SMD = 0.51; 95% CI: 0.34-0.67; p < 0.001; I<sup>2</sup> = 94.0%). Postoperative NLR was also elevated in POAF patients (SMD = 0.30; 95% CI: 0.13-0.47; p < 0.001; I<sup>2</sup> = 70.7%). Among four studies including patients with prior AF (6,364 patients), no significant association was observed (SMD = 0.04; p = 0.21). DTA analysis of 12 studies showed pooled sensitivity of 0.52, specificity of 0.71, and diagnostic odds ratio of 3.74 (AUC = 0.713), indicating moderate diagnostic accuracy.</p><p><strong>Conclusion: </strong>Elevated NLR is associated with increased risk of POAF. Distinguishing new-onset POAF and accounting for surgical type are essential when evaluating NLR as a predictive biomarker.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.7000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Updated Evidence on Perioperative Neutrophil-to-Lymphocyte Ratio in Cardiac Surgery: A Dual Analysis of Prognostic and Diagnostic Value for Postoperative Atrial Fibrillation.\",\"authors\":\"Mohamed K A Awad, Ahmed E Ali, Muhammad S Mazroua, Karim Ali, Radwa K Awad, Toqa R Mohamed, Mohamed Abdelmaksoud, Mahmoud A Hashim, Redi Nikollari, Panos N Vardas, Hussein Abu-Daya\",\"doi\":\"10.1016/j.hrthm.2025.09.036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Post-operative atrial fibrillation (POAF) is a frequent complication after cardiac surgery, increasing morbidity. The neutrophil/lymphocyte ratio (NLR), a simple marker of systemic inflammation, has been studied as a predictor.</p><p><strong>Objective: </strong>Assess association between NLR and new-onset POAF.</p><p><strong>Methods: </strong>We systematically searched PubMed, Scopus, Web of Science, and Embase through June 2025 for studies reporting preoperative or postoperative NLR and incidence of POAF in adult cardiac surgery patients. Diagnostic test accuracy (DTA) was assessed to evaluate the predictive performance of preoperative NLR for postoperative atrial fibrillation, using pooled sensitivity, specificity, and likelihood ratios. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity.</p><p><strong>Results: </strong>Thirty-two studies (20,056 patients) were included. In 27 studies excluding preoperative AF (13,630 patients), POAF was associated with significantly higher preoperative NLR (SMD = 0.51; 95% CI: 0.34-0.67; p < 0.001; I<sup>2</sup> = 94.0%). Postoperative NLR was also elevated in POAF patients (SMD = 0.30; 95% CI: 0.13-0.47; p < 0.001; I<sup>2</sup> = 70.7%). Among four studies including patients with prior AF (6,364 patients), no significant association was observed (SMD = 0.04; p = 0.21). DTA analysis of 12 studies showed pooled sensitivity of 0.52, specificity of 0.71, and diagnostic odds ratio of 3.74 (AUC = 0.713), indicating moderate diagnostic accuracy.</p><p><strong>Conclusion: </strong>Elevated NLR is associated with increased risk of POAF. Distinguishing new-onset POAF and accounting for surgical type are essential when evaluating NLR as a predictive biomarker.</p>\",\"PeriodicalId\":12886,\"journal\":{\"name\":\"Heart rhythm\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Heart rhythm\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.hrthm.2025.09.036\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart rhythm","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.hrthm.2025.09.036","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
背景:术后心房颤动(POAF)是心脏手术后常见的并发症,发病率越来越高。中性粒细胞/淋巴细胞比率(NLR)是一种简单的全身性炎症标志物,已被研究作为一种预测因子。目的:探讨NLR与新发POAF的关系。方法:我们系统地检索PubMed、Scopus、Web of Science和Embase,检索到2025年6月为止关于成人心脏手术患者术前或术后NLR和POAF发生率的研究。采用合并敏感性、特异性和似然比,评估术前NLR对术后房颤的预测性能。采用亚组分析和元回归来探讨异质性的来源。结果:纳入32项研究(20,056例患者)。在27项不包括术前房颤(13,630例)的研究中,POAF与术前NLR显著升高相关(SMD = 0.51; 95% CI: 0.34-0.67; p < 0.001; I2 = 94.0%)。POAF患者术后NLR也升高(SMD = 0.30; 95% CI: 0.13-0.47; p < 0.001; I2 = 70.7%)。在包含既往房颤患者(6,364例)的4项研究中,未观察到显著相关性(SMD = 0.04; p = 0.21)。12项研究的DTA分析显示,合并敏感性为0.52,特异性为0.71,诊断优势比为3.74 (AUC = 0.713),诊断准确性中等。结论:NLR升高与POAF风险增加相关。在评估NLR作为预测性生物标志物时,区分新发POAF和考虑手术类型是必不可少的。
Updated Evidence on Perioperative Neutrophil-to-Lymphocyte Ratio in Cardiac Surgery: A Dual Analysis of Prognostic and Diagnostic Value for Postoperative Atrial Fibrillation.
Background: Post-operative atrial fibrillation (POAF) is a frequent complication after cardiac surgery, increasing morbidity. The neutrophil/lymphocyte ratio (NLR), a simple marker of systemic inflammation, has been studied as a predictor.
Objective: Assess association between NLR and new-onset POAF.
Methods: We systematically searched PubMed, Scopus, Web of Science, and Embase through June 2025 for studies reporting preoperative or postoperative NLR and incidence of POAF in adult cardiac surgery patients. Diagnostic test accuracy (DTA) was assessed to evaluate the predictive performance of preoperative NLR for postoperative atrial fibrillation, using pooled sensitivity, specificity, and likelihood ratios. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity.
Results: Thirty-two studies (20,056 patients) were included. In 27 studies excluding preoperative AF (13,630 patients), POAF was associated with significantly higher preoperative NLR (SMD = 0.51; 95% CI: 0.34-0.67; p < 0.001; I2 = 94.0%). Postoperative NLR was also elevated in POAF patients (SMD = 0.30; 95% CI: 0.13-0.47; p < 0.001; I2 = 70.7%). Among four studies including patients with prior AF (6,364 patients), no significant association was observed (SMD = 0.04; p = 0.21). DTA analysis of 12 studies showed pooled sensitivity of 0.52, specificity of 0.71, and diagnostic odds ratio of 3.74 (AUC = 0.713), indicating moderate diagnostic accuracy.
Conclusion: Elevated NLR is associated with increased risk of POAF. Distinguishing new-onset POAF and accounting for surgical type are essential when evaluating NLR as a predictive biomarker.
期刊介绍:
HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability.
HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community.
The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.