Vijay Kumar Garlapati, Swati Sharma, Deepak Sharma, S P Jeevan Kumar, Samuel Jacob, Arindam Kuila, Ashok Kumar Gupta, Abhishek Chaudhary
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Sustainable production of microalgal nanoparticles through green synthesis towards cancer treatment.
Nanoparticle-based treatment is one of the rapidly growing research domains in cancer treatment due to its associated structural, targeted, and stability features. The conventional (chemical and physical) nanoparticle (NP) synthesis suffers from drawbacks such as toxicity, cost, and unsustainable process methodologies, which necessitate the urgent need for sustainable green approaches to nanoparticle synthesis for envisioned cancer treatment options. The green synthesis of microalgal NPs is a promising approach for obtaining NPs for cancer treatment. As a result, this review presents the synthesis mechanism of microalgal NPs and the factors affecting their green synthesis. The mechanism of action of microalgal NPs in cancer treatment has been discussed in relation to their cytotoxic effects. The sustainability features, probable quality control regime of green-synthesized microlgal NPs, along with the prospects of incorporating synthetic biology and utilizing genetically engineered microalgae, have been highlighted in the context of cancer treatment.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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