Zhuang Ma, Sixuan Zou, Ruoxuan Liu, Song Li, Zhenjiang Li
{"title":"社会经济发展指数（SDI）梯度和高bmi驱动的泛癌症负担：关于死亡率、残疾和健康不平等的全球疾病负担研究（2015-2021）。","authors":"Zhuang Ma, Sixuan Zou, Ruoxuan Liu, Song Li, Zhenjiang Li","doi":"10.1186/s12889-025-24531-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The rising prevalence of high body mass index (BMI) has become a critical driver of global oncologic morbidity and mortality, yet its pan-cancer burden remains poorly characterized across socioeconomic development strata. This study investigates the geographic, temporal, and sex-specific disparities in high BMI-attributable cancer burden, stratified by the Socioeconomic Development Index (SDI), to inform precision public health strategies.</p><p><strong>Methods: </strong>Leveraging the 2021 Global Burden of Disease (GBD) dataset, we analyzed age-standardized mortality, disability-adjusted life years (DALYs), and years of life lost (YLLs) for 17-23 countries across Asia and globally. SDI-stratified analyses evaluated temporal trends (2015-2021) and cancer-type contributions, while multivariable models assessed associations between income inequality (Gini coefficient), healthcare capacity, and metabolic risk exposure.</p><p><strong>Results: </strong>Marked disparities emerged across SDI gradients: high-SDI nations exhibited 6.7-fold higher mortality rates (e.g., Malaysia: 4.40 vs. Bangladesh: 0.65/100,000) and concentrated burdens in colorectal (40.5% DALYs) and breast cancers (27.0% DALYs), contrasting with distributed burdens in low-SDI regions (no cancer > 15.6% DALYs). Gender disparities highlighted male predominance in liver (+ 8.4 DALY difference) and colorectal cancers (+ 5.1), while female-specific malignancies (e.g., uterine cancer) retained consistent burdens across SDI levels. Temporal analyses revealed accelerated DALY reductions in middle-SDI regions (-4.5% annual percent change [APC]) but rising breast cancer burdens in low-SDI settings (+ 1.2% APC). Economic inequality (Gini > 0.40) correlated with elevated mortality (Turkey: 123.1/100,000), independent of GDP, underscoring synergistic impacts of BMI and sociodemographic inequities.</p><p><strong>Conclusion: </strong>High BMI-driven pan-cancer burden is profoundly shaped by SDI gradients, reflecting interactions between metabolic risk, healthcare access, and socioeconomic determinants. Tailored interventions-prioritizing colorectal and breast cancers in high-SDI regions and addressing systemic inequities in low-SDI settings-are critical to mitigating the dual burden of obesity and cancer in transitioning populations.</p>","PeriodicalId":9039,"journal":{"name":"BMC Public Health","volume":"25 1","pages":"3295"},"PeriodicalIF":3.6000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Socioeconomic development index (SDI) gradients and high BMI-Driven pan-cancer burden: a global burden of disease study on mortality, disability, and health inequities (2015-2021).\",\"authors\":\"Zhuang Ma, Sixuan Zou, Ruoxuan Liu, Song Li, Zhenjiang Li\",\"doi\":\"10.1186/s12889-025-24531-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The rising prevalence of high body mass index (BMI) has become a critical driver of global oncologic morbidity and mortality, yet its pan-cancer burden remains poorly characterized across socioeconomic development strata. This study investigates the geographic, temporal, and sex-specific disparities in high BMI-attributable cancer burden, stratified by the Socioeconomic Development Index (SDI), to inform precision public health strategies.</p><p><strong>Methods: </strong>Leveraging the 2021 Global Burden of Disease (GBD) dataset, we analyzed age-standardized mortality, disability-adjusted life years (DALYs), and years of life lost (YLLs) for 17-23 countries across Asia and globally. SDI-stratified analyses evaluated temporal trends (2015-2021) and cancer-type contributions, while multivariable models assessed associations between income inequality (Gini coefficient), healthcare capacity, and metabolic risk exposure.</p><p><strong>Results: </strong>Marked disparities emerged across SDI gradients: high-SDI nations exhibited 6.7-fold higher mortality rates (e.g., Malaysia: 4.40 vs. Bangladesh: 0.65/100,000) and concentrated burdens in colorectal (40.5% DALYs) and breast cancers (27.0% DALYs), contrasting with distributed burdens in low-SDI regions (no cancer > 15.6% DALYs). Gender disparities highlighted male predominance in liver (+ 8.4 DALY difference) and colorectal cancers (+ 5.1), while female-specific malignancies (e.g., uterine cancer) retained consistent burdens across SDI levels. Temporal analyses revealed accelerated DALY reductions in middle-SDI regions (-4.5% annual percent change [APC]) but rising breast cancer burdens in low-SDI settings (+ 1.2% APC). Economic inequality (Gini > 0.40) correlated with elevated mortality (Turkey: 123.1/100,000), independent of GDP, underscoring synergistic impacts of BMI and sociodemographic inequities.</p><p><strong>Conclusion: </strong>High BMI-driven pan-cancer burden is profoundly shaped by SDI gradients, reflecting interactions between metabolic risk, healthcare access, and socioeconomic determinants. Tailored interventions-prioritizing colorectal and breast cancers in high-SDI regions and addressing systemic inequities in low-SDI settings-are critical to mitigating the dual burden of obesity and cancer in transitioning populations.</p>\",\"PeriodicalId\":9039,\"journal\":{\"name\":\"BMC Public Health\",\"volume\":\"25 1\",\"pages\":\"3295\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12889-025-24531-0\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12889-025-24531-0","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Socioeconomic development index (SDI) gradients and high BMI-Driven pan-cancer burden: a global burden of disease study on mortality, disability, and health inequities (2015-2021).
Background: The rising prevalence of high body mass index (BMI) has become a critical driver of global oncologic morbidity and mortality, yet its pan-cancer burden remains poorly characterized across socioeconomic development strata. This study investigates the geographic, temporal, and sex-specific disparities in high BMI-attributable cancer burden, stratified by the Socioeconomic Development Index (SDI), to inform precision public health strategies.
Methods: Leveraging the 2021 Global Burden of Disease (GBD) dataset, we analyzed age-standardized mortality, disability-adjusted life years (DALYs), and years of life lost (YLLs) for 17-23 countries across Asia and globally. SDI-stratified analyses evaluated temporal trends (2015-2021) and cancer-type contributions, while multivariable models assessed associations between income inequality (Gini coefficient), healthcare capacity, and metabolic risk exposure.
Results: Marked disparities emerged across SDI gradients: high-SDI nations exhibited 6.7-fold higher mortality rates (e.g., Malaysia: 4.40 vs. Bangladesh: 0.65/100,000) and concentrated burdens in colorectal (40.5% DALYs) and breast cancers (27.0% DALYs), contrasting with distributed burdens in low-SDI regions (no cancer > 15.6% DALYs). Gender disparities highlighted male predominance in liver (+ 8.4 DALY difference) and colorectal cancers (+ 5.1), while female-specific malignancies (e.g., uterine cancer) retained consistent burdens across SDI levels. Temporal analyses revealed accelerated DALY reductions in middle-SDI regions (-4.5% annual percent change [APC]) but rising breast cancer burdens in low-SDI settings (+ 1.2% APC). Economic inequality (Gini > 0.40) correlated with elevated mortality (Turkey: 123.1/100,000), independent of GDP, underscoring synergistic impacts of BMI and sociodemographic inequities.
Conclusion: High BMI-driven pan-cancer burden is profoundly shaped by SDI gradients, reflecting interactions between metabolic risk, healthcare access, and socioeconomic determinants. Tailored interventions-prioritizing colorectal and breast cancers in high-SDI regions and addressing systemic inequities in low-SDI settings-are critical to mitigating the dual burden of obesity and cancer in transitioning populations.
期刊介绍：
BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.
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