Laura Salavessa, Myckaëla Rouabah, Paula Pernea, Smail Hadj-Rabia, Cédric Delevoye
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Functional and Morphological Plasticity of the Endolysosomal System: Pigment Organelles at the Crossroads of Physiology and Pathology
The endolysosomal system is a highly dynamic and versatile network of organelles essential for maintaining cellular and tissue homeostasis. Its functional diversity relies on a high degree of plasticity, driven by tightly regulated membrane remodeling and intracellular trafficking events. In certain specialized cells, this plasticity enables the formation of lysosome-related organelles, like melanosomes in pigment cells, through the repurposing of ubiquitous membrane trafficking machineries. Disruption of these pathways can lead to pathological conditions, including genetic disorders. In this review, we explore how endolysosomal plasticity underlies key adaptive cellular strategies at the cellular and tissue levels. Focusing on melanocytes, which synthesize melanin, and keratinocytes, which receive and store it, we illustrate how trafficking and membrane dynamics events coordinate between these two cell types for skin pigmentation and photoprotection, and how mutations affecting these processes lead to genetic forms of albinism. By using skin pigmentation as a model of cell- and tissue-specific adaptation, this review highlights the broader physiological and pathological implications of endolysosomal membrane morphodynamics.
期刊介绍:
The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms.
This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.