刺激响应上转换纳米颗粒-嵌入介孔SiO2纳米球用于传递亲疏水抗癌药物和细胞成像。

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS
Neha Dubey, Sonali Gupta, Sandeep B Shelar, Bijaideep Dutta, Kanhu C Barick, Sudeshna Chandra
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引用次数: 0

摘要

核壳结构被广泛报道为通过减少表面淬火和优化能量传递途径来增强上转换纳米粒子(UCNPs)的发光性能。然而,本研究展示了一种混合结构,其中UCNPs (CaF2:Yb3+, Er3+)使用软化学方法嵌入在介孔二氧化硅(m-SiO2)纳米球中,提供了传统核壳结构的替代方案。x射线衍射(XRD)和透射电子显微镜(TEM)的结构分析证实了高结晶立方相萤石型UCNPs在介孔SiO2框架(UCNPs@m-SiO2)中成功捕获。这些UCNPs@m-SiO2具有高表面积,多孔性,良好的胶体稳定性和ph依赖的电荷转换特性,这使得它们非常有利于药物传递应用。这种基于基质的设计不仅稳定了纳米颗粒,而且显著提高了其在近红外(NIR)光照射(980 nm)下的上转换发光性能。此外,二氧化硅基质的多孔性使得抗癌药物盐酸多柔比星(DOX)和姜黄素(CUR)可以被有效地包封,并证明它们在温和的酸性环境中具有持续和可控的ph响应释放。负载药物的系统显示出对乳腺癌(MCF-7)和肺癌(A549)细胞的毒性比单独的对应物(DOX和CUR)增强。此外,开发的UCNPs@m-SiO2在内化到癌细胞后保留了其红色发射能力,因此也可用于细胞成像目的。具体来说,这项工作展示了用于图像引导药物输送应用的水分散、生物相容性和光稳定的UCNPs的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stimuli-Responsive Upconversion Nanoparticles-Embedded Mesoporous SiO2 Nanospheres for Delivery of Hydrophilic and Hydrophobic Anticancer Drugs and Cellular Imaging.

Core-shell architectures are widely reported for enhancing the luminescence properties of upconversion nanoparticles (UCNPs) by minimizing surface quenching and optimizing energy transfer pathways. However, this study demonstrates a hybrid structure in which UCNPs (CaF2:Yb3+, Er3+) are embedded in a mesoporous silica (m-SiO2) nanosphere using a soft chemical approach, offering an alternative to conventional core-shell structures. The structural analysis by X-ray diffraction (XRD) and transmission electron microscopy (TEM) confirmed the successful entrapment of highly crystalline cubic phase fluorite-type UCNPs in a mesoporous SiO2 framework (UCNPs@m-SiO2). These UCNPs@m-SiO2 exhibited a high surface area, porous nature, good colloidal stability, and pH-dependent charge-converting characteristics, which made them extremely conducive for drug delivery application. This matrix-based design not only stabilizes the nanoparticles but also significantly enhances their upconversion luminescence properties upon near-infrared (NIR) light irradiation (980 nm). Furthermore, the porous nature of the silica matrix allows efficient encapsulation of anticancer drugs, doxorubicin hydrochloride (DOX) and curcumin (CUR), and demonstrates their sustained and controlled pH-responsive release with higher release in a mildly acidic environment. The-drug loaded systems showed enhanced toxicity toward breast (MCF-7) and lung (A549) cancer cells over their individual counterparts (DOX and CUR). Moreover, the developed UCNPs@m-SiO2 retained their red emission capability upon internalization into cancer cells and thus can also be used for cellular imaging purposes. Specifically, this work demonstrated the development of water-dispersible, biocompatible, and photostable UCNPs for image-guided drug delivery applications.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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