硼-10直接接触：利用10BF3催化镍催化还原C（sp2）─10B偶联

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-10-03 DOI:10.1002/anie.202513304

Chun-Fu Meng,Bei-Bei Zhang,Shuai Liu,Qiang Liu,Zhi-Xiang Wang,Xiang-Yu Chen

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引用次数: 0

摘要

硼-10同位素（10B）是硼中子俘获治疗（BNCT）的关键；然而，直接使用工业上可用的10BF3来合成富含10b的化合物仍然具有挑战性，因为它具有很强的B─F键。在此，我们提出了一种镍催化的还原方案，可以使用10BF3直接形成C（sp2）─10B键。这种方法利用AlCl3和路易斯碱在原位生成亲电性硼离子。该方法消除了对预功能化硼试剂的需求，为制备多种富含10b的化合物提供了一条有效途径，在BNCT和中子屏蔽材料中具有广阔的应用前景。

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Direct Boron-10 Access: Nickel-Catalyzed Reductive C(sp2)─10B Coupling Utilizing 10BF3.

The boron-10 isotope (10B) is critical for boron neutron capture therapy (BNCT); however, the direct use of industrially available 10BF3 for synthesizing 10B-enriched compounds remains challenging due to the strong B─F bonds. Herein, we present a nickel-catalyzed reductive protocol that enables direct C(sp2)─10B bond formation using 10BF3. This approach employs AlCl3 and a Lewis base to generate electrophilic borenium ions in situ. The method eliminates the need for pre-functionalized boron reagents, providing an efficient route to diverse 10B-enriched compounds with promising applications in BNCT and neutron-shielding materials.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.