主空塞拉。

Q3 Medicine
Natalia Soledad Leon, Soledad Sosa, Nicolas Coronel-Restrepo, Analía Pignatta, Daniel Moncet, Jose Daniel Morando, Monica Graciela Loto, Marisol Escudero, Elizabeth Coronello, Leonardo Luis Rizzo, Karina Danilowicz
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引用次数: 0

摘要

简介:原发性空鞍(PES)包括鞍上蛛网膜下腔在蝶鞍内的突出,患者无鞍病理史。诊断大多是偶然作出的。目的:描述PES患者的特点。方法:纳入1997-2021年间在布宜诺斯艾利斯6家阿根廷神经内分泌中心诊断的PES患者。诊断基于鞍区磁共振,基线激素测量评估垂体功能,神经眼科评估和测量视觉功能。结果:共纳入63例患者,平均年龄52.3±13.2岁,以女性为主(79%,4:1)。平均BMI为32.7±8.13 kg/m2, 68%的人超重或肥胖。59%的患者存在HTA。在妇女中,产次率为78%:92%为多胎妊娠。22%为偶然诊断。在有症状的患者中(n= 49),问诊原因为头痛61%,内分泌功能障碍51%,视力障碍33%,其中43%的患者出现多重症状。MRI显示63%的患者有部分PES, 37%的患者有全部PES。在生化评价中,46%的患者出现垂体功能低下。结论:虽然PES的诊断可能是偶然的,但在我们的研究中,大多数患者都有症状。其中以多产妇女、肥胖和高血压患者居多。应进行生化评价,以调查孤立或多发垂体缺陷,以指示相应的替代治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Primary empty sella

Introduction: Primary empty sella (PES) consists of herniation of the suprasellar subarachnoid space within the sella turcica in patients with no history of sellar pathology. Diagnosis is mostly made incidentally.

Objective: Describe the characteristics of patients with PES.

Methods: Patients with PES from 6 Argentine centers specialized in Neuroendocrinology in Buenos Aires diagnosed between 1997-2021 were included. Diagnosis was based in sellar magnetic resonance, pituitary functional evaluation by baseline hormonal measurement and visual function assessed by neuro-ophthalmological evaluation and campimetry.

Results: Sixty-three patients with a mean age of 52.3 ± 13.2 years and a predominance of female gender (79%, 4:1 ratio) were included. The average BMI was 32.7 ± 8.13 kg/m2 and 68% were overweight or obese. HTA was also found in 59%. Among women, the parity frequency was 78%: 92% had multiple pregnancies. The diagnosis was incidental in 22%. In symptomatic patients (n= 49), the reasons for consultation were headache in 61%, symptoms of endocrine dysfunction in 51% and visual disturbances in 33%: 43% of the patients presented multiple symptoms. MRI showed partial PES in 63% and total PES in 37% of the patients. In the biochemical evaluation, hypopituitarism was observed in 46%.

Conclusions: Although the diagnosis of PES can be made incidentally, in our series most of the patients presented symptoms. Most of them were multiparous women, obese and hypertensive patients. Biochemical evaluation should be carried out to investigate isolated or multiple pituitary deficits in order to indicate the corresponding replacement treatment.

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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
60
审稿时长
20 weeks
期刊介绍: The Journal of the Faculty of Medical Sciences is a scientific publication of the Secretariat of Science and Technology of the Faculty of Medical Sciences of the National University of Cordoba. Its objective is to disseminate and promote research work related to Medical and Biological Sciences. It publishes scientific works of national and international professionals on different topics related to health sciences from the field of medicine, nursing, kinesiology, diagnostic imaging, phonoaudiology, nutrition, public health, chemical sciences, dentistry and related.
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